Lot Consistency Clinical Trial of of Recombinant HPV Bivalent Vaccine in 9 to14 Years Old Healthy Female

Inclusion Criteria:

* 1\. Aged over 9 years old to 14 years old Female at the time of the first vaccine injection;
* 2\. Statutory guardian of the subjects able to provide legal identification or the trustee able to provide the authorization certificate;
* 3\. Judged as healthy and eligible for vaccination by the investigators through a selfreported medical history and some physical examinations;
* 4.Axillary temperature is below than 37.0 ℃;
* 5.Negative for urine pregnancy test.
* 6.The statutory guardian and trustee able to understand this study information and willing to comply with all study requirements(the statutory guardian or subject able to fill in the diary card and attend the follow-up on schedule).
* 7.Willing to participate in this study and sign informed consent form.

Exclusion Criteria:

Exclusion criteria for the first vaccination:

1. Administration of HPV Vaccine before the study;
2. Use of any investigational product or non-registered product (drug or vaccine)within 30 days preceding the first dose of the study vaccine or plan to use during the study period;
3. Received immunosuppressed, immunoregulation therapy or corticosteroid systemic therapy for more than 14 days in the 6 months before entry, except local treatment(such as ointment, eyedrops, inhalants or nasal sprays);
4. Administration of any immunoglobulin or blood products within 3 months preceding the first dose of the study vaccine,or plan to use during the study period;
5. Administration of any inactivated vaccines within 14 days preceding the first dose of the study or attenuated live vaccines within 21 days preceding the first dose of the study;
6. Had a fever (axillary temperature over 38°C) within 3 days or acute illness, or use systemic antibiotics or antiviral treatment within 5 days before vaccination;
7. Participate in any other clinical trial during the study period;
8. Immunodeficiency (such as HIV carriers), primary disease of important organs, malignant tumor, or any immune disease (such as systemic lupus erythematosus, rheumatoid arthritis, splenectomy or functional asplenia or other disease which might affect immune response), or other chronic diseases requiring treatment;
9. History of allergic disease or history of serious adverse events occurring after vaccination, such as allergy,urticaria, dyspnea, angioneurotic edema or abdominal pain;
10. Asthma that needed emergency treatment, hospitalization, oral or intravenous corticosteroid to keep stable in the past two years;
11. Combining another severe internal medicine disease(such as hypertension, cardiopathy,diabetes and hyperthyroidism);
12. Anormal coagulation function or coagulopathy diagnosed by doctor;
13. Epilepsy(not including febrile seizures under 2 years old, alcohol epilepsy within 3 years prior to abstinence and simple epilepsy that have not required treatment within 3 years prior to the study) ;
14. Anormal psychology or mind affecting the individual ability to obey the study requirements. Psychiatric disorders, not controlled in the past two years, required medication, or suicidal tendency in the past five years;
15. Other medical, psychological, social or occupational factors that, according to the investigators' judgment, might affect the individual ability to obey the protocol or sign the informed consent.

Exclusion criteria for second vaccination:

1. History of serious allergic reaction occurring after the first HPV vaccination;
2. History of serious adverse events following immunization caused by the first HPV vaccination;
3. Subject with new discovery or occurrence that does not meet the inclusion criteria, or conform to the exclusion criteria after the first HPV vaccination;
4. According to the judgment of the investigator, subject has newly discovered or emerging severe internal medicine disease, anormal coagulation function or coagulopathy that is not suitable for participating after the first HPV vaccination.