Clinical trial · Interventional
The Effectiveness of Personalized Colorectal Cancer Screening Based on Fecal Hemoglobin Concentration
NCT05423886CI-TRIAL-00059211PERFECT-FITunknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
We aim to improve the yield and effectiveness of the Dutch colorectal cancer screening program by using a personalized screening strategy based on fecal Hemoglobin concentration in previous screening round for participants with a negative fecal immunochemical test (FIT).
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Personalized screening invitation interval | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Intervention arm
- description
- Participants receive a personalized screening invitation interval (1,2 or 3 years) based on their fecal Hemoglobin concentration of the negative fecal immunochemical test in previous round.
- interventionNames
- Other: Personalized screening invitation interval
- type
- NO_INTERVENTION
- label
- Control arm
- description
- Participants receive a standard screening invitation interval (2 years).
Primary outcomes (1)
- measure
- Detection rate of colorectal cancer and advanced adenomas
- timeFrame
- 6 months after the last invitation
- description
- Number of colorectal cancers and advanced adenomas per screened individual
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 56 Years
- Maximum age
- 71 Years
Show eligibility criteria text
Inclusion Criteria: * Previous negative FIT (below the cut-off of 47 microgram per gram feces) Exclusion Criteria: * Previously tested with FIT cut-off of 15 microgram per gram feces
References
Publications (1)
- DERIVEDBreekveldt ECH, Toes-Zoutendijk E, de Jonge L, Spaander MCW, Dekker E, van Kemenade FJ, van Vuuren AJ, Ramakers CRB, Nagtegaal ID, van Leerdam ME, Lansdorp-Vogelaar I. Personalized colorectal cancer screening: study protocol of a mixed-methods study on the effectiveness of tailored intervals based on prior f-Hb concentration in a fit-based colorectal cancer screening program (PERFECT-FIT). BMC Gastroenterol. 2023 Feb 22;23(1):45. doi: 10.1186/s12876-023-02670-1. PMID 36814185