Clinical trial · Observational
The CSTME Associates With the Prognosis of Stage II and III Colorectal Cancer
The Tumor Microenvironment Collagen Signature (CSTME) Associates With the Prognosis of Stage II and III Colorectal Cancer : A Multi-Center Retrospective Observational Cohort Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Colorectal cancer (CRC) is the second most commonly occurring cancer worldwide. Thirty-five percent of CRC patients are diagnosed at stage II/III, and their outcome differs even if they are in the same stage. Previous study found that the microenvironmental collagen is associated with tumor progression and metastasis. Whether tumor microenvironmental collagen signature is associated with colorectal cancer prognosis still remains unknown. We hypothesize that the tumor microenvironmental collagen signature of colorectal cancer is associated with prognosis.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| CSTME | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- High-CSTME
- description
- Patients with high tumor microenvironment collagen signature
- interventionNames
- Other: CSTME
- label
- Low-CSTME
- description
- Patients with low tumor microenvironment collagen signature
Primary outcomes (1)
- measure
- 5-year DFS
- timeFrame
- 5 years followup after surgery
- description
- 5-year disease free survival
Secondary outcomes (1)
- measure
- 5-year OS
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Pathologically diagnosed with colorectal cancer * TNM stages II and III (according to the 8th edition of AJCC Cancer Staging Manual) * Received radical tumor resection surgery Exclusion Criteria: * ASA grade 4 * Preoperative radiotherapy and/or chemotherapy * Hereditary colorectal cancer * Pregnancy
References
Publications (0)
Data not yet available