Clinical trial · Observational
The Purpose of This Study is to Determine the Frequency of Colorectal Cancer in Male and Female Endurance Athletes Between the Ages of 35 and 50
Measuring the Incidence of Colorectal Cancer in Young Endurance Athletes
NCT05419531CI-TRIAL-00099273completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to determine the frequency of colorectal cancer in male and female endurance athletes between the ages of 35 and 50.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| prospective observational study - screening and follow up colonoscopy | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- The rate of young endurance runners' that have adenomatous polyps.
- timeFrame
- 36 months
- description
- 1. Estimate the rate of young endurance runners that have adenomatous polyps. 2. Estimate the rate of young endurance runners that have advanced adenoma and colorectal cancer on screening colonoscopies.
Secondary outcomes (2)
- measure
- Comparison of the rate of young endurance athletes that have adenomatous polyps with that of the historical controls (those in the average risk group).
- timeFrame
- 36 months
- description
- Fisher's Exact test will be used to compare the rates of adenomatous polyps and colorectal cancer between the young endurance athletes and that of the historical controls. 2.3 Secondary Objectives 1. Compare the rate of young endurance runners that have adenomatous polyps with that of the historical controls (those in the average risk group) 2. Compare the rate of young endurance runners that have advanced adenoma and colorectal cancer on screening colonoscopies with that of the historical controls (those in the average risk group).
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 35 Years
- Maximum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria: * Adult males and females 35-50 years of age * Male and female self-reported endurance athletes, defined by at least one of the following: * Run at least two races of 50 miles or more * Run 5 races of 26.2 miles or more * Ability to complete testing in the protocol and make study visits * Able and willing to consent to protocol Exclusion Criteria: * Known or suspected history of inflammatory bowel disease, familial adenomatous polyposis (FAP), or Lynch Syndrome * Concomitant illness that would prevent adequate patient assessment or in the investigators' opinion pose an added risk for study participants. * Anticipated poor compliance * Prisoners or subjects who are involuntarily incarcerated * Persons with decisional incapacity/cognitive impairment * Any history or evidence of severe illness or any other condition that would make the patient, in the opinion of the investigator unsuitable for the study * Subject is involved with a worker's compensation, personal injury, or other legal matters related to their health * Subject is enrolled in a separate interventional clinical trial
References
Publications (20)
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- BACKGROUNDMeyer JE, Narang T, Schnoll-Sussman FH, Pochapin MB, Christos PJ, Sherr DL. Increasing incidence of rectal cancer in patients aged younger than 40 years: an analysis of the surveillance, epidemiology, and end results database. Cancer. 2010 Sep 15;116(18):4354-9. doi: 10.1002/cncr.25432. PMID 20734460
- BACKGROUNDCong YJ, Gan Y, Sun HL, Deng J, Cao SY, Xu X, Lu ZX. Association of sedentary behaviour with colon and rectal cancer: a meta-analysis of observational studies. Br J Cancer. 2014 Feb 4;110(3):817-26. doi: 10.1038/bjc.2013.709. Epub 2013 Nov 21. PMID 24263062
- BACKGROUNDHeer M, Repond F, Hany A, Sulser H, Kehl O, Jager K. Acute ischaemic colitis in a female long distance runner. Gut. 1987 Jul;28(7):896-9. doi: 10.1136/gut.28.7.896. PMID 3498668
- BACKGROUNDSanchez LD, Tracy JA, Berkoff D, Pedrosa I. Ischemic colitis in marathon runners: a case-based review. J Emerg Med. 2006 Apr;30(3):321-6. doi: 10.1016/j.jemermed.2005.05.021. PMID 16677987
- BACKGROUNDCasey E, Mistry DJ, MacKnight JM. Training room management of medical conditions: sports gastroenterology. Clin Sports Med. 2005 Jul;24(3):525-40, viii. doi: 10.1016/j.csm.2005.05.002. PMID 16004918
- BACKGROUNDde Oliveira EP, Burini RC. The impact of physical exercise on the gastrointestinal tract. Curr Opin Clin Nutr Metab Care. 2009 Sep;12(5):533-8. doi: 10.1097/MCO.0b013e32832e6776. PMID 19535976
- BACKGROUNDClausen JP. Effect of physical training on cardiovascular adjustments to exercise in man. Physiol Rev. 1977 Oct;57(4):779-815. doi: 10.1152/physrev.1977.57.4.779. No abstract available.