Clinical trial · Interventional
a Pilot Study of Lidocaine Infusion for Postoperative Analgesia in Elderly Patients With Colorectal Cancer Surgery
a Pilot Randomized Controlled Trial on the Safety and Efficacy of Different Doses of Lidocaine Infusion for Postoperative Analgesia in Elderly Patients With Colorectal Cancer Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
patients who meet the enrollment criteria will be randomized 1:1:1:1 to the different doses of lidocaine or the placebo group. In the lidocaine groups, at the beginning of surgery, lidocaine 0.5mg/kg, 1.0mg/kg, and 1.5mg/kg per hour were continuously infused (using ideal body weight) respectively during the whole procedure. In contrast, the control group was infused with the same dose of normal saline. All the infusion procedures will be stopped at the end of surgery
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 0.9% NaCl | Drug | — | UNRESOLVED |
| Lidocaine Hydrochloride 2% Injection Solution | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- EXPERIMENTAL
- label
- IVL0.5 group
- description
- At the beginning of surgery, lidocaine 0.5mg/kg per hour will be continuously infused (using ideal body weight) and stopped at the end of the procedure.
- interventionNames
- Drug: Lidocaine Hydrochloride 2% Injection Solution
- type
- EXPERIMENTAL
- label
- IVL1.0 group
- description
- At the beginning of surgery, lidocaine 0.5mg/kg per hour will be continuously infused (using ideal body weight) and stopped at the end of the procedure.
- interventionNames
- Drug: Lidocaine Hydrochloride 2% Injection Solution
- type
- EXPERIMENTAL
- label
- IVL1.5 group
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 60 Years
Show eligibility criteria text
Inclusion Criteria: * Age over 60 years old； * American Society Anesthesiologygist(ASA)I\~III； * Patients scheduled for colorectal cancer surgery； * The surgery takes more than two hours Exclusion Criteria: * BMI≥30kg/㎡or BMI≤18kg/㎡； * Combined with other organ malignancies； * Chronic opioid use, substance abuse, contraindication to the use or incompatibility of any drug in the study； * Patients with liver and kidney insufficiency and chronic pain at the surgical site； * Accompanied by severe heart disease (such as severe atrioventricular block, severe heart failure, etc.)； * A history of uncontrolled seizures or acute porphyria； * Patients who have taken other experimental drugs or participated in or are participating in other clinical trials within 3 months before being enrolled in the study
References
Publications (0)
Data not yet available