Diagnostic Accuracy of a Panel of Bacterial Gene Markers (M3) for Colorectal Advanced Neoplasia

Inclusion Criteria:

1. They require elective colonoscopy for colorectal cancer screening or polyp surveillance, or investigation of symptoms (e.g. anemia, change of bowel habit, abdominal pain);
2. Aged ≥18 years old;
3. Written informed consent obtained.

Exclusion Criteria:

1. Contraindications to colonoscopy (e.g. perforation, intestinal obstruction, unstable cardiopulmonary status);
2. Contraindication to polyp resection (e.g. active gastrointestinal bleeding, uninterrupted anticoagulation or dual antiplatelets);
3. Known colorectal cancer or adenoma for staged procedure;
4. Previous colonic resection;
5. Personal history of colorectal cancer;
6. Personal history of polyposis syndrome;
7. Personal history of inflammatory bowel disease;
8. Known pregnancy or lactation;
9. Advanced comorbid conditions (defined as American Society of Anesthesiologists grade 4 or above);