Clinical trial · Interventional
AZA + Venetoclax as Maintenance Therapy in Younger Adults With AML in First Remission
Randomized, Multicenter, Phase 3 Study of Azacytidine (AZA) + Venetoclax as Maintenance Therapy in Patients With AML in Remissionin Younger Adults With Favorable-risk AML in First Remission After Conventional Chemotherapy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This phase III trial is conducted to evaluate if azacitidine in combination with venetoclax as maintenance therapy improves relapse-free survival (RFS) for younger adults with favorable-risk acute myeloid leukemia (AML) who remained in first complete remission (CR1) following intensive consolidation.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Acute Myeloid Leukemia (AML) in Remission | Acute Myeloid Leukemia | CURATED_BROADER | 0.80 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Azacitidine | Drug | Azacitidine | ALIAS |
| Supportive care | Other | — | UNRESOLVED |
| Venetoclax | Drug | Venetoclax | ALIAS |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Treatment (azacytidine+venetoclax)
- description
- Participants will receive azacytidine QD, on Days 1-5 and venetoclax QD, on Days 1-14 of each 28-day cycle for 8 cycles.
- interventionNames
- Drug: Azacitidine
- Drug: Venetoclax
- Other: Supportive care
- type
- EXPERIMENTAL
- label
- Comparator ( best supportive care)
- description
- Participants will receive observation and supportive care during remission.
- interventionNames
- Other: Supportive care
Primary outcomes (1)
- measure
- Relapse-free survival (RFS)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 64 Years
Show eligibility criteria text
Inclusion Criteria: 1. Diagnosis of favorable-risk acute myeloid leukemia (AML) according to revised 2017 European LeukemiaNet genetic risk stratification and are not immediate candidates for allogeneic stem cell transplant. 2. Aged 18-64 years. 3. Patients who have received remission induction therapy and 3-4 HiDAC or medium-dose cytarabine-based consolidation and are in their first remission. 4. ECOG performance status of \< or = 3. 5. Adequate organ function as follows: 1. Serum total bilirubin \< or = to 3 X the Upper Limit of Normal (ULN) 2. Aspartate Transaminase and alanine transaminase \< or = to 3 x ULN 3. Ccr（Creatinine Clearance Rate) \> or ＝60 ml/min 4. Left ventricular ejection fraction \> or ＝50% determined by ultrasound. 6. For females of childbearing age, they should have a negative serum or urine pregnancy test within 10 to 14 days of enrolling. 7. For males of childbearing age, they should take effective contraceptive methods throughout the treatment period and up to 30 days after discontinuing treatment. 8. Ability to understand and sign informed consent. Exclusion Criteria: 1. Acute promyeloid leukemia. 2. Patients with active central nervous system (CNS) leukemia. 3. Previously diagnosed with myelodysplastic syndrome (MDS) or myeloproliferative neoplasm(MPN) and progressed to AML. 4. Patients with other progressive malignancies. 5. Evidence of other clinically significant uncontrolled condition(s) including, but not limited to uncontrolled and/or active systemic infection (viral, bacterial or fungal). 6. Patients who have participated in other trials within 30 days before signing the informed consent. 7. Females who are pregnant or lactating or intending to become pregnant during the study.
References
Publications (0)
Data not yet available