Clinical trial · Interventional
SDF Application in Oral Cancer Patients to Prevent Dental Caries
Silver Diamine Fluoride: Novel Addition to the Prophylactic Bundle for Dental Management of Radiation-Induced Dental Caries in Oral and Pharyngeal Cancer Patients
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The Texas A \& M College of Dentistry, with partner Texas Oncology-Baylor Charles A. Sammons Cancer-Center Radiation-Oncology, proposes to conduct a preliminary clinical study (NIH Stage 0) to pilot test a randomized clinical trial of the efficacy of professionally applied 38% silver diamine fluoride to prevent tooth decay in 60 patients who are being treated with radiation for life threatening head and neck cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Dental Caries | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| silver diamine fluoride, 38% | Device | — | UNRESOLVED |
| Sodium fluoride gel, 5000 PPM | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Package
- description
- Topical application of 38% silver diamine fluoride plus 5000 PPM fluoride gel 1 mo before and 1 and 3 months after radiation treatment
- interventionNames
- Device: silver diamine fluoride, 38%
- Device: Sodium fluoride gel, 5000 PPM
- type
- ACTIVE_COMPARATOR
- label
- Gel Alone
- description
- Placebo application of silver diamine fluoride plus 5000 PPM fluoride gel 1 mo before and 1 and 3 months after radiation treatment
- interventionNames
- Device: Sodium fluoride gel, 5000 PPM
Primary outcomes (1)
- measure
- Dental Caries (DMFS)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosis of Head and Neck cancer Exclusion Criteria: * Prognosis less than 1 year * Radiation field of treatment does not involve jaws
References
Publications (1)
- DERIVEDNoureldin AAK, Sones A, Mendoza L, Mancl L, Milgrom P. Effectiveness of silver diamine fluoride in preventing radiation-induced caries: A pilot study. J Am Dent Assoc. 2026 Jul 16:S0002-8177(26)00340-5. doi: 10.1016/j.adaj.2026.05.008. Online ahead of print. PMID 42461172