IRD at Admission Predicts Survival of GBM Patients - a Prospective Pilot Study

Glioblastomas (GBM) are the most common primary malignant brain tumor with a very high recurrence rate and an average survival of 14 months. Identifying an imaging biomarker to predict recurrence is critical. Using a special MRI technique called diffusion weighted imaging (DWI), a recent retrospective study described isolated restricted diffusion (IRD) foci. The presence of IRD was found in 40% of patients with GBM on index imaging and was associated with longer survival. IRD foci are not currently identified as having a tumor focus and are not included in treatment strategies and guidelines. These findings need to be confirmed in a prospective study. The investigators propose a prospective pilot study to establish the incidence of IRD on the index imaging of patients with GBM. The investigators will collect surgical samples from these foci to establish the histological and molecular signature to confirm GBM in these newly identified foci. The results from this pilot study will guide the planning of a larger well powered multicenter study that will help establish IRD as an imaging biomarker in the GBM management guidelines, which will help improve the outcomes in patients with GBM.

Sex

All

Minimum age

18 Years

Inclusion Criteria:

* At least 18 years old
* Patients with suspected GBM on initial MRI of brain
* MRI scans with isolated restricted diffusion foci noted

Exclusion Criteria:

* Participants who are pregnant
* Known contraindication to MRI contrast agent, e.g., allergy or anaphylactic reaction
* Known end-stage renal disease