A Phase 1 Study of TRS005 in Patients With R/R CD20-positive B-NHL.

Inclusion Criteria:

1. Histologically confirmed CD20-positive B-cell non-Hodgkin lymphoma;
2. Relapse or refractory after receiving at least 2 standard treatment regimens;（Definition of refractory: Patients who did not reach PR in two cycles or CR in four cycles）;
3. At least 1 measurable tumor lesion, the maximum transverse diameter of the intranodal lesion should be \> 1.5 cm and that of the extranodal lesion should be \> 1.0 cm; CLL/SLL patients have treatment indications according to iwCLL 2018 guidelines;
4. Previously received anti-tumor treatment (such as radiotherapy, chemotherapy, hormone therapy, biotherapy, immunotherapy) at least 28 days before the first administration of this study; chemotherapy and hormono therapy should be at least 14 days before the first administration of this study; Chinese medicine anti-tumor treatment should be at least 7 days before the first administration of this study
5. The toxicity of previous anti-tumor treatment has been restored to ≤ grade 1 as defined by NCI-CTCAE v5.0 (except for alopecia; see Inclusion Criterion 6 for hemoglobin and renal function)；
6. The laboratory test results must meet the following requirements: (It is not allowed to give any blood components, short acting cell growth factor, albumin, etc., within 7 days before laboratory examination; long acting cell growth factor is not allowed to be given within the first 14 days):

   * Hematology: Absolute neutrophil count (ANC) ≥ 1.5×109/L, platelets (PLT) ≥ 90×109/L, hemoglobin (HGB) ≥ 90 g/L;
   * Liver function: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 3 times the upper limit of normal, total bilirubin (TBIL) ≤ 1.5 times the upper limit of normal, (AST and/or ALT ≤ 5 times the upper limit of normal are allowed in patients with liver involvement);
   * Renal function: Serum creatinine (Cr) ≤ 2 times the upper limit of normal;
   * Coagulation function: (patients who have not received anticoagulant treatment before enrollment) International normalized ratio (INR) ≤ 1.5 times the upper limit of normal and activated partial thromboplastin time (APTT) ≤ 1.5 times the upper limit of normal;
   * Pulmonary function test for patients with previous lung underlying disorders: measured/predicted value of vital capacity (VC) ≥ 60%, or diffusing capacity of the lungs for carbon monoxide (DLCO) ≥ 50% of predicted value;
7. ≥ 18 years , gender is not limited;
8. ECOG performance status 0-1;
9. Life expectancy of greater than 3 months;
10. Female and male patients of childbearing age and their spouses are willing to carry out adequate contraception throughout the study period, and female patients of childbearing age must have negative serum pregnancy test within 7 days before the first administration;
11. Patients voluntarily agree to participate in the study and to sign the informed consent form.

Exclusion Criteria:

Patients who meet any of the following criteria will be excluded:

1. A clear history of drug allergy, and a history of ingredient allergy to heterogeneous proteins, biological agents or test drugs;
2. Active hepatitis B or C, or human immunodeficiency virus (HIV) antibody positive;
3. Those who are positive for syphilis antibodies and confirmed to be unresolved;
4. Tumor-infiltrating diseases of the central nervous system;
5. Accompanied by peripheral or central nervous system diseases;
6. Investigator-assessed diabetes uncontrolled by drug therapy;
7. Uncontrollable or symptomatic pleural/abdominal/pelvic effusion or pericardial effusion;
8. Patients with other malignancies within the past 5 years;
9. With active autoimmune diseases (such as systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, Sjogren's syndrome, autoimmune thrombocytopenia, etc.);
10. Accompanied by the following serious cardiovascular diseases or central nervous system diseases:

    1. Myocardial infarction in nearly 6 months of screening period;
    2. Unstable angina pectoris in the screening period of nearly 3 months;
    3. Cardiac insufficiency (cardiac function grade ≥ NYHA class II);
    4. Severe arrhythmia (e.g., persistent ventricular tachycardia, ventricular fibrillation);
    5. Prolonged QTc interval (male \> 450 ms, female \> 470 ms);
    6. Second or third degree heart block;
    7. Drug-poorly controlled hypertension (systolic blood pressure \> 160mmHg or diastolic blood pressure \> 100mmHg);
    8. Cerebrovascular accident (CVA) or transient ischemic attack (TIA), etc., within 6 months before the administration.
11. Other serious diseases, including but not limited to active peptic ulcer, active hemorrhage, venous thromboembolic event (VTE) and severe interstitial lung disease;
12. Accompanied by other serious diseases and serious active infections (such as pneumonia, active tuberculosis, etc.);
13. Received hematopoietic growth factor treatment within 1 week prior to first administration, including colony stimulating factor, interleukin or blood transfusion;
14. The dosage of steroid hormone (prednisone phase equivalent) used greater than 20mg/ day within 1 month prior to first administration for more than 14 consecutive days or immunosuppressive treatment;
15. Various vaccines were inoculated within 1 month prior to first administration;
16. Major surgery (except diagnostic biopsy) within 1 month prior to first administration;
17. Patients who received autologous stem cell transplantation within 2 months prior to first administration;
18. Patients who have received allogeneic stem cell transplantation in the past;
19. Patients with infusion reaction above grade III after previous monoclonal antibody treatment;
20. Participate in clinical trials of other drugs or medical devices within 1 month prior to first administration;
21. Patients previously treated with CAR-T;
22. Investigators assessed as unsuitable to participate in this study for other reasons.