Chemoradiation Plus Tislelizumab for Conversion Therapy of Locally Nonresectable ESCC

Inclusion Criteria:

1. Histologically confirmed ESCC；
2. Clinical stage T4 N-/+，or T1-3 N+（IIIb-IVa） (AJCC 8 TNM classiftion);
3. Locally advanced ESCC that are not resectable for primary site and/or lymph nodes evaluated before treatment;
4. At least one measurable lesion in accordance with RECIST 1.1;
5. Have a performance status of 0 or 1 on the ECOG Performance Scale;
6. Expected survival time is greater than 6 months;
7. The important organs' functions meet the following requirements: the absolute neutrophil count(ANC) ≥1.5×10\^9/L; the platelet count ≥100×10\^9/L; hemoglobin ≥90g/L; bilirubin is less than or equal to 1.5 times ULN, ALT and AST less than or equal 2.5 times UILN; creatinine clearance rate (CCr) ≥50mL/min; the thyroid function is normal;
8. Female subjects of childbearing potential have a negative pregnancy test and must agree to take effective contraceptive measures during the study period and within 3 months after the last dose;
9. Be willing and able to provide written informed consent/assent for the trial.

Exclusion Criteria:

1. The patient has received radiotherapy, chemotherapy, hormone therapy, surgery, or molecular-targeted therapy;
2. Confirmed patients with distant metastasis by CT imaging;
3. The subject has previous or co-existing other malignancies (except cured basal cell carcinoma of the skin and carcinoma in situ of the cervix);
4. The subject had previously received other anti-PD-1 antibody therapy or other immunotherapy targeting PD-1 / PD-L1;
5. Patients with active autoimmune disease or documented autoimmune disease or symptoms requiring systemic hormone therapy or anti-autoimmune drug therapy;
6. Patients with immunodeficiency or who were still receiving systemic steroid hormone therapy (prednisone \> 10 mg/ day or other equivalent drugs) or other forms of immunosuppressive therapy 7 days prior to the first dose of neoadjuvant therapy in this study;
7. Clinical ascites or pleural effusion requiring therapeutic puncture or drainage;
8. The subject with uncontrol cardiac clinical symptoms or diseases, such as (1) any class 2 or more heart failure (2) unstable angina pectoris (3) myocardial infarction within 1 year (4) clinically significant ventricular or ventricular arrhythmias requiring treatment or intervention;
9. Abnormal coagulation function (PT\>16s, APTT\>43s, TT\>21s, Fbg\> 2G /L), bleeding tendency, or receiving thrombolytic or anticoagulant treatment;
10. The subject is present (within 3 months) with esophageal varices, active gastric and duodenal ulcers, ulcerative colitis, portal hypertension, and other gastrointestinal diseases, or with active bleeding from unresected tumors, or other conditions that may cause gastrointestinal bleeding or perforation as determined by the investigator;
11. Past or present severe bleeding (bleeding \>30 ml within 3 months), hemoptysis (fresh blood \>5 ml within 4 weeks) or thromboembolism events (including stroke events and/or TRANSIENT ischemic attack) within 12 months;
12. Patients with active infection who still required systemic treatment 7 days before the first dose of neoadjuvant therapy in this study;
13. Patients with past or present objective evidence of pulmonary fibrosis, interstitial pneumonia, pneumoconiosis, radioactive pneumonia, drug-related pneumonia, severely impaired lung function, etc;
14. Senior or uncontrolled virus injection: HIV, TP, hepatitis virus;
15. Patients who had participated in clinical trials of other drugs within 4 weeks;
16. The live vaccine was administered less than 4 weeks prior to study administration or possibly during the study period;
17. Have a history of mental illness or psychiatric substance abuse;
18. The subject cannot or does not agree to bear the cost of the self-paid portion of the examination and treatment, except for the clinical study drug, combined chemoradiotherapy, and SAE associated with the clinical study drug;
19. Other patients whom the medical practitioner considers inappropriate for inclusion.