Cohort Study of Patients With Hepatocellular Carcinoma and Circulating Tumor DNA Monitoring of Chemoembolization

Inclusion Criteria:

* Age ≥ 18 years
* HCC diagnosed on consensus radiological criteria in cirrhotic patients (EASL-EORTC 2012): helical CT or MRI with triple arterial, portal, and late acquisition. The diagnosis is based on the presence of hypervascularization at the early arterial time (wash-in) with wash-out (hypodensity or hypointensity compared with non-tumor liver parenchyma) at the portal phase or late phase compared with non-tumor parenchyma.
* Histologically diagnosed HCC in the absence of an imaging diagnosis
* Patient with a first TACE (naive) or not, regardless of the number of previous procedures
* Patient naïve or on a new line of oncological treatment, regardless of the number of previous lines of treatment.
* Treatment decision validated by the digestive oncology staff.
* Patient having read and understood the information letter and signed the informed consent.
* Patient follow-up performed at the Charles Nicolle University Hospital in Rouen.

Exclusion Criteria :

* Other active cancer or hematological malignancy, currently being treated
* Patient not affiliated to the social security system
* Pregnant woman or woman in labour or breastfeeding
* Person deprived of liberty by an administrative or judicial decision
* Person placed under court protection