Clinical trial · Interventional
Study of Prostate Perfusion Before Embolization in Patients With Symptomatic Prostate Adenoma
Study of Prostate Perfusion Before Embolization in Patients With Symptomatic Prostate Adenoma. A Single-center Prospective Cohort Pilot Study to Determine the Predictive Factors of Clinical Efficacy Associated With a Prior Phantom Study.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Over the last 5 years, prostate embolization has developed as a treatment for symptomatic prostate adenoma. This long, complex procedure is effective in 80% of cases. Currently there are no means of better selecting patients to avoid this long procedure in non-responders. The hypothesis is that prostate perfusion parameters are correlated with the efficacy of embolization. Studying these prostate perfusion parameters in perfusion CT and evaluating prostate Iodine load in dual energy computed tomography will make it easier to select those patients who are most likely to respond.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Perfusion CT scanning | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Patients benefitting from a perfusion CT scan before embolization
- description
- Prostatic perfusion parameters seem to be correlated with the effectiveness of embolization. Studying these prostatic perfusion parameters in perfusion CT and evaluating the prostatic Iodine load in dual energy CT will make it possible to better select responder patients.
- interventionNames
- Other: Perfusion CT scanning
Primary outcomes (15)
- measure
- Catheterized patients: Removal of the urinary catheter at 3 months
- timeFrame
- Month 3
- description
- Yes/No
- measure
- Non-catheterized patients: 25% decrease in the International Prostate Symptom Score
- timeFrame
- Month 3
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with symptomatic benign prostatic hypertrophy (prostate volume \> 50, IPSS \>7, QoL\>2) or patients catheterized after acute retention of urine with failed catheterization. * Creatinine clearance \> 30 mL/min for one of the two Cockcroft-Gault/MDRD equations) * Adult patients (≥18 years). * Patients with an indication for prostate embolization. * Patient with free and informed consent. * Patient who have signed the consent form. * Patient affiliated or beneficiary of a health insurance plan. Exclusion Criteria: * Hypersensitivity to the active substance or to one of the excipients of the iodized contrast medium. * Severe renal impairment with renal function \<30mL/min. * Contraindication to prostate embolization (aorto-iliac bypass) * Patient participating in research defined as Category 1 Research Involving Human Subjects. * Patient in an exclusion period as determined by another study. * Patient under court protection, guardianship or curatorship. * Patient unable to give consent. * Patient for whom it is impossible to give informed information.
References
Publications (0)
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