Clinical trial · Interventional
Bone-sparing Chemoradiotherapy for Anal Cancer - DACG-II
Bone-sparing Chemoradiotherapy for Anal Cancer - A Prospective Phase II Trial Danish Anal Cancer Group Study
NCT05385250CI-TRIAL-00079828DACG-IIunknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study proposal includes a prospective clinical trial of bone sparing treatment planning in anal cancer patients. the trial aim to lower the risk of bone damage, while adhering with the constrains to the bowel, bladder and other conventional Organs At Risk, and finally to describe the fraction of pelvic insufficiency fractures in patients treated with optimized radiotherapy.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anal Cancer | Malignant Anal Neoplasm | CURATED_EXACT | 0.92 |
| Radiotherapy Side Effect | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Bone sparring radiotherapy | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- Bone sparring radiotherapy
- description
- Observational arm of bone-sparing radiotherapy
- interventionNames
- Other: Bone sparring radiotherapy
Primary outcomes (1)
- measure
- Rate of PIFs
- timeFrame
- 1 year
- description
- Rate of pelvic insufficience fractures (PIF) on MRI
Secondary outcomes (6)
- measure
- Rate of symptomatic PIFs
- timeFrame
- after 1 and 3 year
- description
- Rate of symptomatic Pelvic insufficiency fractures (PIF)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with biopsy verified localized squamous cell anal cancer * Indication for standard (chemo)-radiotherapy with curative intend for anal cancer as per multidisciplinary team decision * Clinical eligible for standard (chemo)-radiotherapy as per physicians' decision * Written and oral consent * Age at least 18 years Exclusion Criteria: * Previous pelvic radiotherapy * Previous systemic therapy with severe bone marrow suppression or hematological diseases * Hip-replacements * Contraindications to MRI-scan
References
Publications (0)
Data not yet available
No reference posted for this study.