Clinical trial · Observational
Deformable Image Registration for Breast Adaptive Tomotherapy
Quantitative Evaluation of the Performance of a Deformable Registration Algorithm: Single-center Study Aimed at Implementing a New Off-line Adaptive Radiotherapy Technique in the Treatment of Breast Cancer by Tomotherapy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The radiotherapy treatment plan (also called dosimetry) used for all treatment sessions is based on the dosimetric scanner. During the sessions, the anatomy of the breast may vary, and these variations may impact the quality of the treatment. Adaptive radiotherapy is a new technique that allows these changes to be taken into account during treatment by automatically rescheduling the treatment for each session. The proposed trial aims to clinically evaluate one of these adaptive radiotherapy tools (PreciseART) based on deformable registration in order to determine if it can be used in daily practice in the treatment of breast cancer by tomotherapy. The trial will also clarify whether factors, such as duration of treatment, impact the quality of this algorithm.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Complete Positioning scans | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (2)
- measure
- Differences between dosimetric metrics on deformed and delineated contours.
- timeFrame
- Before treatment
- description
- Description of the differences between metrics calculated on delineated contours and contours deformed by artificial intelligence
- measure
- Differences between dosimetric metrics on deformed and delineated contours.
- timeFrame
- Mid-treatment : after fraction 7 for patients with 15 fractions (theoretically at day 9) or after fraction 12 for patients with 25 fractions (theoretically at day 16)
- description
- Description of the differences between metrics calculated on delineated contours and contours deformed by artificial intelligence
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: Female * With invasive breast carcinoma (or axillary lymphadenopathy whose pathological examination is compatible with the origin of breast cancer but without an identified primary breast tumor) * Breast surgery (conservative surgery or mastectomy) * Treated by (neo)adjuvant chemotherapy or hormonotherapy * eligible to normo-fractionated breast radiotherapy in 25 sessions of 2 Gray or 15 sessions of 2.67 Gray, associated or not to bed irradiation whatever the delivered dose * eligible to an irradiation of sus-clavicular, inner mammary chain or axillary lymph nodes * With helicoidal tomotherapy Exclusion Criteria: * Absence of indication for breast radiotherapy * Absence of indication for lymph nodes irradiation * partial irradiation of breast * in situ carcinoma * intranodal isolated tumor cells * radiotherapy on prosthesis or surgically reconstructed breast * antecedent of breast irradiation opr homolateral lymh node irradiation * bilateral breast cancer
References
Publications (0)
Data not yet available