Clinical trial · Interventional
Endodontic Microsurgery With the Use of L-PRF Block
Endodontic Microsurgery With the Use of L-PRF Block: a Randomized Controlled Clinical Trial
NCT05379010CI-TRIAL-00069643unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study evaluates the effect of leucocyte and platelet rich fibrin Block (L-PRF Block) during endodontic microsurgery (EMS) on patient's post-operative comfort and periapical bone healing in large peri-apical lesions.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Apical Periodontal Cyst | — | UNRESOLVED | — |
| Apical Periodontitis | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Endodontic Microsurgery | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- With L-PRF Block
- interventionNames
- Procedure: Endodontic Microsurgery
- type
- ACTIVE_COMPARATOR
- label
- No L-PRF Block
- interventionNames
- Procedure: Endodontic Microsurgery
Primary outcomes (1)
- measure
- Amount of peri-apical bone healing
- timeFrame
- 1 year
- description
- Amount of periapical bone healing in time: measured with Cone Beam Computed Tomography (CBCT).
Secondary outcomes (6)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria * Provision of Informed Consent * Patients from 18 years old * Patients in need of an EMS * EMS is the only option to cure the periapical lesion * A periapical lesion that has a diameter of 10mm or more in sagittal plane, frontal plane or axial plane when measured on CBCT Exclusion Criteria * Unlikely to be able to comply with the study procedures, as judged by the investigator * Orthograde endodontic (re)treatment is indicated * Known or suspected current malignancy * History of chemotherapy within 5 years prior to study * History of radiation in the head and neck region * History of other metabolic bone diseases * History of bleeding disorders * HIV disease * Hepatitis B or C * Systemic disease (osteoporosis, diabetes…)
References
Publications (0)
Data not yet available
No reference posted for this study.