Clinical trial · Observational
Retrospective Analysis of Colorectal Cancer Screening Results
Retrospective Analysis of Colorectal Cancer Screening Results Among People Aged 40-74 in Shipai Town, Dongguan City, China
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to retrospectively analyze colorectal cancer screening data of 40-74 year old population in Shipai Town, Dongguan City. In this study, the data of SDC2 Gene Methylation Test and Fecal Immunochemistry Test (Q-FIT) were screened from about 11,000 subjects who participated in Colorectal Cancer Screening in Shipai Town People's Livelihood Project from May 2021 to May 2022. Data from 822 subjects with positive SDC2 Gene Methylation Test and/or positive Fecal Immunochemistry Test (Q-FIT) results and with colonoscopy and/or pathological results were selected for retrospective analysis. This retrospective study evaluated the screening performance of SDC2 Gene Methylation Test and/or Fecal Immunochemistry Test (Q-FIT) for colorectal cancer using colonoscopy and/or pathological results as the clinical standard method.
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Advanced Adenocarcinoma | Adenocarcinoma | CURATED_BROADER | 0.78 |
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Colorectal Neoplasms | Colorectal Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Digestive System Neoplasm | Digestive System Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Hyperplastic Polyp | — | UNRESOLVED | — |
| Neoplasms | Neoplasm | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Colonoscopy and/or pathological examination | Procedure | — | UNRESOLVED |
| SDC2 Gene Methylation Test and Q-FIT Test | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- Subjects with positive SDC2 Gene Methylation Test
- description
- Subjects must meet both of the following criteria to be eligible for the study: 1. Subjects with positive SDC2 Gene Methylation Test; 2. Subjects with colonoscopy results and/or pathological results.
- interventionNames
- Diagnostic Test: SDC2 Gene Methylation Test and Q-FIT Test
- Procedure: Colonoscopy and/or pathological examination
- label
- Subjects with positive Q-FIT Test
- description
- Subjects must meet both of the following criteria to be eligible for the study: 1. Subjects with positive Q-FIT Test; 2. Subjects with colonoscopy results and/or pathological results.
- interventionNames
- Diagnostic Test: SDC2 Gene Methylation Test and Q-FIT Test
- Procedure: Colonoscopy and/or pathological examination
- label
- Subjects with positive SDC2 Gene Methylation Test and Q-FIT Test
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
- Maximum age
- 74 Years
Show eligibility criteria text
Inclusion Criteria: Subjects must meet both of the following criteria to be eligible for the study: 1. Subjects with positive SDC2 Gene Methylation Test and/or Q-FIT; 2. Subjects with colonoscopy and/or pathological results. Exclusion Criteria: Subject with any of the following conditions shall be excluded: 1. Data Missing or damaged; 2. Unqualified colonoscopy or unqualified stool test.
References
Publications (1)
- DERIVEDKong X, Wu Q, Zhang Z, Yu Z, Niu F, Wang X, Zou H. Effectiveness of single-target fecal DNA methylation test in regional mass screening for colorectal cancer and precancerous lesions in China. Gastroenterol Rep (Oxf). 2025 Apr 15;13:goaf029. doi: 10.1093/gastro/goaf029. eCollection 2025. PMID 40241850