Collecting Ducts Carcinoma: in Depth Exploration and Biologically Driven Therapy (CICERONE)

* Collect a large number of samples with certain / suspected diagnosis of collecting duct carcinoma in order to confirm the diagnosis (centralized review) and standardize according to WHO 2016 criteria * Build an extensive tissue bank (DNA and RNA extraction) aimed at defining the molecular taxonomy of the tumor through 1) transcriptomic analysis 2) gene expression profile * Define specific molecular signatures

Sex

All

Minimum age

18 Years

Maximum age

85 Years

Inclusion Criteria:

* Age ≥ 18 years
* Signature of consent (for patients enrolled in the prospective part of the study)
* Histological diagnosis of renal cell carcinoma of the Bellini collecting duct RCC

Exclusion Criteria:

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• BACKGROUNDBecker F, Junker K, Parr M, Hartmann A, Fussel S, Toma M, Grobholz R, Pflugmann T, Wullich B, Strauss A, Behnes CL, Otto W, Stockle M, Jung V. Collecting duct carcinomas represent a unique tumor entity based on genetic alterations. PLoS One. 2013 Oct 22;8(10):e78137. doi: 10.1371/journal.pone.0078137. eCollection 2013. PMID 24167600
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• BACKGROUNDMalouf GG, Comperat E, Yao H, Mouawad R, Lindner V, Rioux-Leclercq N, Verkarre V, Leroy X, Dainese L, Classe M, Descotes JL, Barthelemy P, Yacoub M, Roupret M, Bernhard JC, Creighton CJ, Spano JP, Su X, Khayat D. Unique Transcriptomic Profile of Collecting Duct Carcinomas Relative to Upper Tract Urothelial Carcinomas and other Kidney Carcinomas. Sci Rep. 2016 Aug 3;6:30988. doi: 10.1038/srep30988. PMID 27484008
• BACKGROUNDWang J, Papanicolau-Sengos A, Chintala S, Wei L, Liu B, Hu Q, Miles KM, Conroy JM, Glenn ST, Costantini M, Magi-Galluzzi C, Signoretti S, Choueiri T, Gallucci M, Sentinelli S, Fazio VM, Poeta ML, Liu S, Morrison C, Pili R. Collecting duct carcinoma of the kidney is associated with CDKN2A deletion and SLC family gene up-regulation. Oncotarget. 2016 May 24;7(21):29901-15. doi: 10.18632/oncotarget.9093.