Efficacy and Safety of Tixel Treatment on Facial and/or Scalp Actinic Keratoses.

Inclusion Criteria:

1. Male and female, age 18-80 years old.
2. Skin Phototype I-VI.
3. Subject has mild to moderate thickness confluent AKs on his/her scalp and/or face.
4. Subject is willing and able to comply with protocol requirements and all study visits.
5. Subject has provided written informed consent.

Exclusion Criteria:

1. Any patient who has undergone tanning during the 4 weeks prior to any treatment session and/or any patient who plans to undergo tanning during the 4 weeks following any treatment session (patients who may be exposed to the sun for short periods of time occasionally are not contra-indicated as long as they apply a high SPF sunscreen (\>50).
2. Current active Herpes Simplex infection.
3. Current skin cancer, malignant sites and/or advanced premalignant lesions or moles in the treatment area.
4. An impaired immune system condition or use of immunosuppressive medication.
5. Collagen disorders, keloid formation and/or abnormal wound healing.
6. Any patient who takes or has taken any medications (including via topical application), herbal treatment (oral or topic), food supplements or vitamins, which may cause fragile skin or impaired skin healing during the last 3 months.
7. Any patient who has used oral retinoids within 6 months prior to treatment or less.
8. Any patient who has a history of bleeding coagulopathies.
9. Any patient who has tattoos or permanent makeup in the treated area.
10. Any patient who has burned skin, blistered skin, irritated skin, or sensitive skin in any of the areas to be treated.
11. Women who are pregnant (as determined by self-reporting), lactating, or less than 3 months post-delivery, possibly pregnant or planning a pregnancy during the study period.
12. Currently participating in or recently participated in another clinical trial (within the last 30 days).
13. Prior treatment with ablative laser, any laser or photo-dynamic therapy 3 months prior to enrollment.
14. Any cryotherapy or electrodessication 6 weeks prior to enrollment.
15. Systemic retinoid therapy within 6 months prior to enrollment, topical treatment with 5-Fluorouracil cream and/or imiquimod cream and/or diclofenac gel 6 months prior to enrollment.
16. Prior treatment with Tixel.
17. Face cannot be treated due to dermal disorder other than AKs, such as infection, surgical treatment etc.
18. Subject has a systemic disease manifested by AKs (e.g. immune suppression).
19. Significant systemic illness.