Clinical trial · Observational
Molecular Characterisation of Appendiceal Cancer
Characterisation of Appendiceal Cancer by Genomic and Transcriptomic Analysis and Correlation With Clinical Outcomes
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Patients ≥ 18 years old who have been diagnosed with appendiceal cancer with peritoneal metastases, have had cytoreductive surgery, have availability of archival tumour tissue and have consented to our institutional biobank program or have a waiver of consent for deceased patients who have not had the opportunity to provide biobank consent (requested at the time of ethics review). Descriptive analysis of the proportion of genetic mutations identified in appendiceal cancers. This is given by the percentage of pathogenic mutations in the peritoneal metastasis compared to the primary tumour.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Appendiceal Cancer | Malignant Appendix Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Retrospective tissue sample analysis | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- All participants
- description
- Appendiceal Cancer Patients
- interventionNames
- Other: Retrospective tissue sample analysis
Primary outcomes (1)
- measure
- Characterise the genes of appendiceal cancer.
- timeFrame
- 2 years
- description
- Descriptive analysis of the proportion of genetic mutations identified in appendiceal cancers. This is given by the percentage of pathogenic mutations in the peritoneal metastasis compared to the primary tumour.
Secondary outcomes (1)
- measure
- Descriptive analysis in proportions
- timeFrame
- 2 years
- description
- The descriptive difference in proportion of genetic mutations identified in primary appendiceal tumours compared to mutations in peritoneal metastases. Association between molecular subtypes and categorical variables were measured by Fisher's exact or X2 tests. Associations with continuous variables will be evaluated by Kruskal-Wallis tests or ANOVA. Kaplan-Meier methods will calculate survival outcomes.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: Participants are eligible to be included in the study only if all of the following criteria apply: 1. Patients ≥ 18 years old who have been diagnosed with appendiceal cancer with peritoneal metastases, 2. have had cytoreductive surgery 3. have availability of archival tumour tissue Exclusion Criteria: * None
References
Publications (0)
Data not yet available