A Clinical Study to Observe the Effectiveness and Safety of IBI310, Bevacizumab Combined With Sintilimab in the Treatment of Advanced Hepatocellular Carcinoma

Inclusion Criteria:

1. Histologically/cytologically confirmed hepatocellular carcinoma, or meeting the clinical diagnostic criteria for hepatocellular carcinoma ;
2. Aged ≥18 years,≤75 years;
3. ECOG performance status score of 0 or 1 point;
4. Barcelona Clinic Liver Cancer (BCLC) stage C, or Stage B not suitable for radical surgery and/or local treatment;
5. No systemic antitumor treatment for hepatocellular carcinoma before the first administration;
6. At least 1 measurable lesion according to the Response Evaluation Criteria in Solid Tumors Version 1.1(RECIST V1.1), or measurable lesion with definite progression after local treatment (based on RECIST V1.1 criteria);
7. Child-Pugh Class A or B(≤7);
8. Adequate organ and bone marrow function.
9. Expected life time is over 12 weeks.
10. Take effective contraceptive measures
11. Willing to attend the study and having given the ICF

Exclusion Criteria:

1. Known fibrolamellar HCC, sarcomatoid HCC, mixed cholangiocarcinoma and HCC
2. History of hepatic encephalopathy or liver transplantation
3. Pleural, ascites, and pericardial effusion with clinical symptoms requiring drainage
4. HBV-DNA\>2000 IU/ML or 10\^4 copies/ml；Untreated positive HCV-RNA；HbsAg and anti-HCV antibody were both positive
5. History of GI bleeding within 6 months, or severe (G3) varices at endoscopy within 3 months
6. Arteriovenous embolism within 6 months
7. The tumor thrombus involved both main and branch portal veins, main portal veins and mesenteric veins or inferior vena cava.
8. Antiplatelet drugs were administered for 10 days for therapeutic purposes 2 weeks before administration
9. Uncontrolled hypertension
10. Unrecovered AE（\>CTCAE grade 1） due to previous treatment
11. Heart failure (NYHA Classification III-IV), or poorly controlled arrhythmias
12. History of gastrointestinal perforation, fistula, intestinal obstruction, extensive bowel resection, Crohn's disease, ulcerative colitis, or chronic diarrhea
13. With lung fibrosis, interstitial lung disease, pneumoconiosis, drug-associated pneumonia and serious impairment in lung function
14. Active tuberculosis
15. Infected with HIV or syphilis
16. Severe infections that are active or clinically poorly controlled
17. Use of immunosuppressive drugs within 4 weeks prior to initial dosing
18. Receipt of live attenuated vaccine within 4 weeks prior to randomization
19. Significant traumatic injury or major surgical procedure within 28 days prior to randomization
20. Other conditions that the investigator judged inappropriate for inclusion
21. Prior immunotherapy or targeted therapy
22. Treatment of Traditional Chinese medicine with anti-tumor indications or drugs with immunomodulatory effects whitin 2 weeks
23. Pregnant or breast-feeding women