Clinical trial · Interventional
Health and Energy Through Active Living Every Day After Cancer Intervention for Cancer Survivors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of the Health and Energy through Active Living Every Day (HEALED) intervention, is to examine the effect of a web-based intervention on changes in device-measured physical activity (light and moderate-to-vigorous intensity aerobic) and sedentary behavior. The purpose of this study is intended for survivors of a cancer with a 5-year survival (at Stage I, II, and III) of at least 45% that has a strong level of evidence for association with physical inactivity according to the 2018 PA Guidelines Advisory Committee Report (breast, colon, endometrium, kidney, bladder, multiple myeloma). In line with social cognitive theory behavior change techniques, participants will be provided information and skills necessary to be more physically active and less sedentary after a cancer diagnosis. New materials will be disseminated biweekly through a website open only to participants, and include at-home exercise demonstration videos, research news, discussion boards, success stories, infographics for exercise recommendations, etc.
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anxiety | — | UNRESOLVED | — |
| Cognitive Decline | — | UNRESOLVED | — |
| Depression | — | UNRESOLVED | — |
| Fatigue | — | UNRESOLVED | — |
| Quality of Life | — | UNRESOLVED | — |
| Sleep | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Balance and flexibility control | Behavioral | — | UNRESOLVED |
| Physical activity experiment | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Physical Activity Group
- description
- Physical activity (PA) group participants will receive behavioral nudge e-mails with links to a web-based platform which will provide: physical activity information, at-home exercise demonstrations/videos for survivors of all fitness levels, articles, blog posts, physical activity/sitting recommendations, a space for goal setting, a platform for physical activity tracking, a discussion board, automatic syncing of their Fitbit to the leaderboard, etc.
- interventionNames
- Behavioral: Physical activity experiment
- type
- ACTIVE_COMPARATOR
- label
- Balance and Flexibility Group
- description
- The static Balance and Flexibility (BF) website will include infographics, videos, and articles for participants to view at their leisure. They will receive access to the HEALED website at the end of the 12-month intervention period.
- interventionNames
- Behavioral: Balance and flexibility control
Primary outcomes (2)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 55 Years
- Maximum age
- 77 Years
Show eligibility criteria text
Inclusion Criteria: * Are a survivor of Stage I - III breast, colon, endometrium, kidney, or bladder cancer, or of multiple myeloma (verified through medical record abstraction/tumor tissue or state registry, to which participants have already consented) * Are a part of the CPS-3 Portal (this also implies that an email address is on file and an English survey response) * Must have a physical, continental US street address where they can receive shipments for 12 months. * Have access to a working smartphone or tablet * Are not currently pregnant * Exercise less 300 minutes per week * Did not register for HEALED Study pilot (n = 99; conducted in 2019, published in 2021; Appendix 11, AM12\_IRB00059007 approved in February 2019) * Are able to walk assisted Exclusion Criteria: * A doctor has recommended that they avoid moderate or vigorous exercise, or limit walking * Have received any of the following treatments for their cancer diagnosis in the last 6 months: Surgery to remove the cancer, chemotherapy, radiation therapy, or immunotherapy. * Have major planned surgery in the next 12 months
References
Publications (3)
- BACKGROUNDRees-Punia E, Leach CR, Westmaas JL, Dempsey LF, Roberts AM, Nocera JR, Patel AV. Pilot Randomized Controlled Trial of Feasibility, Acceptability, and Preliminary Efficacy of a Web-Based Physical Activity and Sedentary Time Intervention for Survivors of Physical Inactivity-Related Cancers. Int J Behav Med. 2022 Apr;29(2):220-229. doi: 10.1007/s12529-021-09999-5. Epub 2021 May 6. PMID 33954891
- DERIVEDChiang KE, Masters M, Whalen S, Donzella S, Bates-Fraser LC, Peoples AR, Zhong C, Sullivan K, Hartman SJ, Patel AV, Rees-Punia E. The Impact of a Physical Activity Intervention on Cognitive and Mental Health Outcomes in Cancer Survivors. Psychooncology. 2026 Aug;35(8):e70588. doi: 10.1002/pon.70588. PMID 42640227
- DERIVEDRees-Punia E, Masters M, Whalen S, Hartman SJ, Sullivan K, Westmaas JL, Teras LR, Patel AV. Digital intervention for increasing physical activity and reducing sedentary behaviour in cancer survivors: a trial within the Cancer Prevention Study-3 cohort. Br J Sports Med. 2025 Jul 31;59(16):1143-1150. doi: 10.1136/bjsports-2024-109332. PMID 40461052