Clinical trial · Interventional
Effects of Propofol on Auditory Event-related Potentials and Brain Functional Connectivity in Patients With Supratentorial Glioma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The growth of gliomas often infiltrates important brain tissues and impairs subcortical fiber transmission, resulting in changes in global brain network connectivity. Most of the current anesthesia depth monitoring methods are based on healthy brain function population，which is difficult to reflect the sedation depth of glioma patients accurately. Therefore, this study aims to explore the characteristics of brain network connectivity in glioma patients under different sedation depths by electroencephalogram (EEG) and auditory event-related potential (AERP) methods, which may provide a research basis for sedative titration and anesthesia depth identification in glioma patients.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Auditory Event-related Potential (AERP) | — | UNRESOLVED | — |
| Brain Network Connectivity | — | UNRESOLVED | — |
| Electroencephalogram (EEG) | — | UNRESOLVED | — |
| Glioma | Glioma | ONTOLOGY_EXACT | 0.98 |
| Propofol | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Propofol Injection | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Healthy volunteers
- interventionNames
- Drug: Propofol Injection
- type
- EXPERIMENTAL
- label
- supratentorial glioma patients
- interventionNames
- Drug: Propofol Injection
Primary outcomes (2)
- measure
- The amplitude of auditory event-related potential
- timeFrame
- During the trial(up to 3 hours for each subject)
- description
- The amplitude of MMN and P300
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 60 Years
Show eligibility criteria text
Inclusion Criteria: 1. Age 18 - 60 years old; 2. American Society of Anesthesiologists (ASA) physical status rating I-II; 3. Supratentorial glioma (frontal, temporal, parietal, insular ；WHO grade I-III); 4. Native Chinese speaker; 5. Signed informed consent. Exclusion Criteria: 1. Mallampati airway class≥III; 2. BMI\>30kg/m2; 3. Combined OSAS or Stop-BANG score≥3; 4. Hearing impairment 5. Combined epilepsy symptoms 6. Recurrent or multiple intracranial tumors 7. Concomitant other psychiatric or neurological disorders 8. Pregnancy and lactation
References
Publications (0)
Data not yet available