Clinical trial · Interventional
A Clinical Study of Herombopag in Tumors-associated Thrombocytopenia
A Prospective, Multi-cohort, Open-label Clinical Study of the Efficacy and Safety of Herombopag in Tumors-associated Thrombocytopenia
NCT05350956CI-TRIAL-00058108unknownPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to confirm the safety and efficacy of Herombopag in tumors-associated thrombocytopenia
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Tumor Therapy-related Thrombocytopenia | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| TPO-RA (Herombopag) | Drug | — | UNRESOLVED |
| TPO-RA (Herombopag) and rhTPO(Recombinant human thrombopoietin) | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Herombopag monotherapy
- interventionNames
- Drug: TPO-RA (Herombopag)
- type
- EXPERIMENTAL
- label
- Herombopag is treated in combination with rhTPO(Recombinant human thrombopoietin)
- interventionNames
- Drug: TPO-RA (Herombopag) and rhTPO(Recombinant human thrombopoietin)
Primary outcomes (1)
- measure
- During the correction period, the percentage of patients whose platelets returned to normal within 14 days
- timeFrame
- up to 14 days
- description
- Percentage of patients whose platelets returned to normal within 14 days
Secondary outcomes (11)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Age ≥18, no gender limitation; 2. Participants with solid tumors confirmed by histopathological or cytological examination; 3. During the current tumor treatment cycle, the participants whose PLT\<50×109/L, and will receive the current tumor treatment regimen for at least 1 cycle; 4. Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2. 5. Voluntarily participated in the study and signed the informed consent with good compliance. Exclusion Criteria: 1. Suffering from any of the following diseases of the hematopoietic system other than thrombocytopenia caused by tumor therapy, including but not limited to leukemia, primary immune thrombocytopenia, myeloid proliferative disease, multiple myeloma and myelodysplastic syndrome; 2. Suffering from thrombocytopenia (not caused by tumor treatment), including but not limited to chronic liver disease, hypersplenism, infection, and bleeding, within 6 months prior to screening; 3. Bone marrow invasion or bone marrow metastasis; 4. Received radiation therapy to the pelvis, spine and bone field within 3 months prior to screening; or is/is expected to receive radiation therapy. 5. Received TPO-RA drugs (such as altrepopal and romistine), or rhTPO or rhIL-11 in the current cancer treatment cycle; 6. Received platelet transfusion within 3 days prior to randomization; 7. Participants with known or expected allergy or intolerance to the active ingredient or excipient of Herombopag Olamine tablets; 8. Pregnant or lactating women; 9. Participants who are participating in other clinical trials. 10. Other conditions that the investigator determines are not suitable for inclusion in the study.
References
Publications (0)
Data not yet available
No reference posted for this study.