Clinical trial · Interventional
MORPHEE : Mechanisms of Cell Death Induced by Extracorporeal Photochemotherapy
NCT05333367CI-TRIAL-00082841MORPHEErecruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The objective of this study is to describe the type of cell death induced by extracorporeal photochemotherapy, depending on the cell type, using a panel of complementary analysis techniques.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cutaneous T-Cell Lymphoma | Primary Cutaneous T-Cell Non-Hodgkin Lymphoma | ALIAS | 0.90 |
| Graft Rejection | — | UNRESOLVED | — |
| Graft Vs Host Disease | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Samples collection | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- Patients undergoing extracorporeal photochemotherapy
- interventionNames
- Other: Samples collection
Primary outcomes (3)
- measure
- Type of cell death induced by 8-MOP sensitization and UVA irradiation
- timeFrame
- 24 hours
- description
- Caspase-3 activation in Western blot
- measure
- Type of cell death induced by 8-MOP sensitization and UVA irradiation
- timeFrame
- 24 hours
- description
- Gasdermin D cleavage in Western blot
- measure
- Type of cell death induced by 8-MOP sensitization and UVA irradiation
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: * Adult patients * Treated with ECP for at least 1 month, for control of GVHD in hematopoietic cell allograft (acute or chronic GVHD), treatment and control of cellular or humoral rejection in solid organ transplantation (heart, lung, kidney) or in the treatment of cutaneous T-cell lymphoma Exclusion Criteria: * Subjects with limited legal capacity. * Subjects judged by the investigator to be unlikely to comply with study procedures * Subjects with no social security coverage. * Pregnant women. * Subjects still in the exclusion period of another study, or according to the national registry of clinical trial participants.
References
Publications (0)
Data not yet available
No reference posted for this study.