Clinical trial · Interventional
Ramosetron on Late PONV (Postoperative Nausea and Vomiting)
The Effect of Additional Administration of Ramosetron on Late PONV (Postoperative Nausea and Vomiting) in Patients Undergoing Breast Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study was to evaluate the effectiveness of additional ramosetron injection for controlling late postoperative nausea and vomiting (PONV) after breast surgery in high risk PONV patients. The investigators compared PONV amomng 3 groups- group C: no additional ramosteron, group B: two additional ramosteron doses at 12 hour interval, group M: two additional ramosetron doses mix to the intraveonus patient controlled analgesia.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer Female | — | UNRESOLVED | — |
| Postoperative Nausea and Vomiting | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Ramosetron Hydrochloride | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- NO_INTERVENTION
- label
- group C
- description
- receive ramosetron i.v. 0.3mg at the end of surgery without additional ramosetron
- type
- EXPERIMENTAL
- label
- group B
- description
- receive ramosetron i.v. 0.3mg at the end of surgery with two additional doses of ramosetron at 12- and 24- hour postoperative time points
- interventionNames
- Drug: Ramosetron Hydrochloride
- type
- EXPERIMENTAL
- label
- group M
- description
- receive ramosetron i.v. 0.3mg at the end of surgery followed ramosetron 0.6 mg mix with the patient-controlled analgesia (PCA) regimen
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * age over 18 years * American Society of Anesthesiologists (ASA) physical status I or II * requesting IV PCA (patient control of analgesia) for pain control * the high-risk group of PONV with a score of 3 or more as measured by the Apfel's score. Exclusion Criteria: * emergency operation * re-operation * drug abuse, allergy * major organ disease (gastrointestinal, cardiovascular, respiratory, cerebral, renal or hepatic disease) * smoker * pregnancy * lactation * previously use of antiemetics or systemic steroids within 48 before surgery
References
Publications (0)
Data not yet available