Clinical trial · Observational
Patient Derived Preclinical Models
NCT05324553CI-TRIAL-00114148recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Study goal is to collect tumor specimens that may inform cancer biology to eventually improve outcomes for patients with cancer. This proposal represents a highly collaborative effort to support cancer research with the goal of developing novel therapeutic strategies using patient derived preclinical models. This study is being done to collect samples of tumor tissues, matched normal tissue when possible, and approximately 50 mL of blood.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Blood Collection | Diagnostic Test | — | UNRESOLVED |
| Buccal Swab | Diagnostic Test | — | UNRESOLVED |
| Tissue Collection | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- Tissue Collection
- description
- Research tissue specimen will be obtained during the patient's clinical biopsy or clinical tumor resection, if feasible.
- interventionNames
- Procedure: Tissue Collection
- label
- Blood Collection
- description
- Up to 50 mL of research blood will be drawn around the time of the procedure. Additional blood may be collected in selected cases, as warranted, to monitor disease recurrence/remission or perform additional testing
- interventionNames
- Diagnostic Test: Blood Collection
- label
- Buccal Swab
- description
- Buccal swab may be requested, if necessary, to generate germline data.
- interventionNames
- Diagnostic Test: Buccal Swab
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * 18 years of age and older * Patient is a good medical candidate for a standard of care or research biopsy or surgical procedure to obtain tissue Exclusion Criteria: * Uncontrolled concurrent illness including psychiatric illness, or situations that would limit compliance with the study requirements or the ability to willingly give written informed consent * Institutionalized or incarcerated patients * Inaccessible tumor for biopsy or patient does not have tumor tissue available for research use * Biopsy must not be considered more than minimal risk to the patient. * Have a contraindication to percutaneous biopsy including: 1. Significant coagulopathy that cannot be adequately corrected. 2. Severely compromised cardiopulmonary function or hemodynamic instability. 3. Lack of a safe pathway to the lesion per the interventional radiologist. 4. Inability of the patient to cooperate with, or to be positioned for, the procedure.
References
Publications (0)
Data not yet available
No reference posted for this study.