Clinical trial · Observational
Sensitivity of Multiparametric MRI in Differentiation Between Muscle Invasive and Non-muscle Invasive Urinary Bladder Cancer
NCT05324033CI-TRIAL-00065274completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Differentiation between non-muscle-invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC) is a cornerstone in the treatment plans.Therefore, this study will try to evaluate the sensitivity and reliability of mpMRI in accurate diagnosis of cancer bladder. Primary objective: to detect the sensitivity of multiparametric MRI in differentiation between muscle Invasive and non-muscle invasive Urinary Bladder Cancer in relation to the conventional cystoscopy and histopathological examination of the biopsy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer, Bladder | Malignant Bladder Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| diagnostic cystoscopy +/- TURBT | Procedure | — | UNRESOLVED |
| multiparametric MRI on the bladder | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- muscle invasive cancer bladder
- interventionNames
- Radiation: multiparametric MRI on the bladder
- Procedure: diagnostic cystoscopy +/- TURBT
- label
- non-muscle invasive cancer bladder
- interventionNames
- Radiation: multiparametric MRI on the bladder
- Procedure: diagnostic cystoscopy +/- TURBT
Primary outcomes (1)
- measure
- to detect the sensitivity of multiparametric MRI in differentiation between muscle Invasive and non-muscle invasive Urinary Bladder Cancer in relation to the conventional cystoscopy and histopathological examination of the biopsy.
- timeFrame
- 6 month
Secondary outcomes (1)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * All patients diagnosed with NMIBC or MIBC during diagnostic cystoscopy or by any radiologic investigation in the Urology department of Helwan university hospitals without being restricted to age or sex. * All histological types of bladder cancer * Newly diagnosed, recurrent cases, or even patients undergoing follow-up cystoscopy. Exclusion Criteria: * Patients with elevated renal function according to their age as this will be a contraindication to DCE MRI. * Patients with absolute contraindication to MRI (e.g.: metallic prosthesis). * Patients with contraindication to undergo TURBT (e.g.: unfit for surgery).
References
Publications (24)
- BACKGROUNDBjurlin MA, Carroll PR, Eggener S, Fulgham PF, Margolis DJ, Pinto PA, Rosenkrantz AB, Rubenstein JN, Rukstalis DB, Taneja SS, Turkbey B. Update of the Standard Operating Procedure on the Use of Multiparametric Magnetic Resonance Imaging for the Diagnosis, Staging and Management of Prostate Cancer. J Urol. 2020 Apr;203(4):706-712. doi: 10.1097/JU.0000000000000617. Epub 2019 Oct 23. PMID 31642740
- BACKGROUNDShampo MA, Kyle RA, Steensma DP. Richard Ernst--Nobel Prize for nuclear magnetic resonance spectroscopy. Mayo Clin Proc. 2012 Dec;87(12):e109. doi: 10.1016/j.mayocp.2012.01.023. No abstract available. PMID 23218094
- BACKGROUNDBochner BH, Dalbagni G, Sjoberg DD, Silberstein J, Keren Paz GE, Donat SM, Coleman JA, Mathew S, Vickers A, Schnorr GC, Feuerstein MA, Rapkin B, Parra RO, Herr HW, Laudone VP. Comparing Open Radical Cystectomy and Robot-assisted Laparoscopic Radical Cystectomy: A Randomized Clinical Trial. Eur Urol. 2015 Jun;67(6):1042-1050. doi: 10.1016/j.eururo.2014.11.043. Epub 2014 Dec 8. PMID 25496767
- BACKGROUNDChang SS, Bochner BH, Chou R, Dreicer R, Kamat AM, Lerner SP, Lotan Y, Meeks JJ, Michalski JM, Morgan TM, Quale DZ, Rosenberg JE, Zietman AL, Holzbeierlein JM. Treatment of Non-Metastatic Muscle-Invasive Bladder Cancer: AUA/ASCO/ASTRO/SUO Guideline. J Urol. 2017 Sep;198(3):552-559. doi: 10.1016/j.juro.2017.04.086. Epub 2017 Apr 26. PMID 28456635
- BACKGROUNDChavhan, G. (2013). MRI Made Easy (for beginners) (2nd ed., pp. 2-16). JAYPEE BROTHERS MEDICAL PUBLISHERS (P) LTD.
- BACKGROUNDCheung G, Sahai A, Billia M, Dasgupta P, Khan MS. Recent advances in the diagnosis and treatment of bladder cancer. BMC Med. 2013 Jan 17;11:13. doi: 10.1186/1741-7015-11-13. PMID 23327481
- BACKGROUNDDeGeorge KC, Holt HR, Hodges SC. Bladder Cancer: Diagnosis and Treatment. Am Fam Physician. 2017 Oct 15;96(8):507-514.