Nutritional Support During Induction Therapy for Esophageal Cancer

Patients diagnosed with esophageal cancer have difficulty eating, as the food pipe becomes obstructed by the cancer. This may impair the ability for the patient to receive appropriate calorie intake, especially during administration of chemotherapy and radiation therapy given prior to surgical resection. A strategy is to place a feeding tube directly in the stomach or in the small bowel to have an access to the patient's gastrointestinal tract during administration of chemo radiation therapy. However, these feeding tubes may lead to adverse events, including dislodgement, infection, the tube may be plugged, etc. If these complications were to happen, patients may have their treatment delayed, may have to come to the emergency department or even be admitted. In some cases, patients may need to have a surgery performed to treat the complication. Most centres in Canada have moved away from placement of these feeding tubes due to the high incidence of complications associated with the feeding tubes placement, and due to the high efficacy from the chemoradiation therapy in shrinking the tumour, allowing for the patient to swallow. In London, the preference from the Medical and Radiation Oncologists was to have these feeding tubes placed to avoid delay in treating the patients. There is therefore significant controversy as to what is the best approach in this patient population. Our goal is to run a feasibility randomized controlled trial studying this question.

Sex

All

Minimum age

18 Years

Inclusion Criteria:

* Adult patient
* Non-cervical biopsy-proven esophageal or gastroesophageal junction (Siewert I or II) cancer
* Patient eligible for induction therapy then esophagectomy (stage Ib to III)

Exclusion Criteria:

* Impossibility to pass an endoscope beyond the tumour
* metastatic disease
* early-stage disease with either upfront esophagectomy or endoscopic resection planned
* patient refusal of the feeding tube
* inability to swallow their pill
* inability to tolerate a full fluid diet