Clinical trial · Interventional
Testing a Cognitive Behavioral Model for Reducing Dyspnea in Patients With Lung Cancer
A Pilot Study to Test a Cognitive-Behavioral Model for Dyspnea in Patients With Lung Cancer
NCT05304793CI-TRIAL-00082101completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This trial studies the effect of a form of cognitive-behavioral therapy, Take a Breath, on reducing the intensity and frequency of dyspnea (difficulty breathing) in patients with lung cancer. Take a Breath consists of individual therapy sessions that educate patients on dyspnea and provides coping strategies.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Non-Small Cell Carcinoma | Lung Non-Small Cell Carcinoma | CURATED_BROADER | 0.80 |
| Lung Small Cell Carcinoma | Lung Small Cell Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Best Practice | Other | — | UNRESOLVED |
| Cognitive Behavior Therapy | Behavioral | — | UNRESOLVED |
| Questionnaire Administration | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Arm I (TAB)
- description
- Patients participate in 4 weekly TAB in-person or video conference sessions over 1 hour each that provide them with skills to cope with their dyspnea. Patients also receive treatment handouts, a CD with an audio file with instructions for progressive muscle relaxation, and a pulse oximeter. Patients may receive additional support calls over 10-15 minutes from the TAB provider within 1 week following each session.
- interventionNames
- Behavioral: Cognitive Behavior Therapy
- Other: Questionnaire Administration
- type
- ACTIVE_COMPARATOR
- label
- Arm II (usual care)
- description
- Patients receive usual management of dyspnea from the treating physician.
- interventionNames
- Other: Best Practice
- Other: Questionnaire Administration
Primary outcomes (5)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosed with non-small cell lung cancer (NSCLC) or small cell lung cancer (SCLC) * Currently experiencing dyspnea as defined by a score \>= 1 on the American Thoracic Society (ATS) Dyspnea Questionnaire within 3 weeks of enrollment * Seeking medical oncology care and treatment at the Ohio State University Comprehensive Cancer Center (OSUCCC) Thoracic Oncology Clinic * Ability to understand and willingness to sign an informed consent document Exclusion Criteria: * Presence of other serious comorbidities that would interfere with patients' study participation (e.g., serious mental illness, heart disease) as determined by the treating oncologist * Life expectancy \< 2 months * History of surgery for lung cancer
References
Publications (1)
- DERIVEDLo SB, Arrato NA, Presley CJ, McGinty HL, Otto MW, Andersen BL. Cognitive-Behavioral Treatment for Breathlessness in Lung Cancer: A Randomized Controlled Trial. Ann Am Thorac Soc. 2025 Oct;22(10):1579-1591. doi: 10.1513/AnnalsATS.202406-580OC. PMID 40772929