Clinical trial · Interventional
Effect of Bevacizumab on Asymptomatic Radiotherapy-induced Brain Injury
Effect of Bevacizumab on Asymptomatic Radiotherapy-induced Brain Injury in Patients With Head and Neck Cancer
NCT05303259CI-TRIAL-00057411BRAINunknownPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To investigate the effect of Bevacizumab on asymptomatic radiotherapy-induced brain injury patients with head and neck cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Injuries | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Bevacizumab | Drug | Bevacizumab | ALIAS |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- HNC patients with radiation-induced brain injury.
- description
- Bevacizumab 2.5mg/kg， q2w，4 cycles.
- interventionNames
- Drug: Bevacizumab
- type
- NO_INTERVENTION
- label
- HNC patients without brain injury after radiotherapy.
- description
- No treatment.
Primary outcomes (1)
- measure
- The incidence and duration of onset of clinical symptoms.
- timeFrame
- Change form baseline to evaluation at 1 year.
- description
- The incidence and duration of onset of clinical symptoms within 1 year after treatment between the treatment group and the control group.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: Head MRI confirmed RI lesions. Sign the informed consent. Exclusion Criteria: With clinical symptoms of RI lesions. Head MRI showed bleeding lesions Contraindications of Bevacizumab. Pregnant women and parturient women.
References
Publications (0)
Data not yet available
No reference posted for this study.