Clinical trial · Interventional
Serratus Anterior Plane Block for Modified Radical Mastectomy: Double-point VS Single-point
The Analgesic Effect of Ultrasound-guided Double-point Versus Single-point Serratus Anterior Plane Block on Modified Radical Mastectomy：A Randomized Controlled Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Nowadays, the incidence of breast cancer is the first number of malignant tumors, and the primary treatment method is surgery. As is known to all, less postoperative complications and enhanced recovery are closely related to effective analgesia. However, postoperative patients often experience moderate pain, while associated with axillary discomfort. Serratus Anterior Plane Block (SAPB) relieves postoperative pain, but traditional single point block method has no effect on axillary discomfort. Therefore, it is necessary to try double point blocks to explore their impact on postoperative analgesia and axillary comfort. This RCT will recruit patients proposed to undergo Modified Radical Mastectomy (MRM) and be randomized to single point or double point groups to evaluate their postoperative pain score and axillary comfort in order to provide clinical guidance.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Mammary Cancer | — | UNRESOLVED | — |
| Postoperative Pain | — | UNRESOLVED | — |
| Serratus Anterior Plane Block | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Double-point SAPB | Procedure | — | UNRESOLVED |
| Single-point SAPB | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Double-point SAPB
- description
- SAPB will be performed simultaneously in both the third and fifth rib levels.
- interventionNames
- Procedure: Double-point SAPB
- type
- EXPERIMENTAL
- label
- Single-point SAPB
- description
- SAPB will be performed only in the fifth rib level.
- interventionNames
- Procedure: Single-point SAPB
Primary outcomes (1)
- measure
- Postoperative pain severity at 24 h
- timeFrame
- 24 hours after the surgery
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * Patients are proposed to undergo Modified Radical Mastectomy * Patients with American Society of Anesthesiologists (ASA) physical status I\~III * aged 18-70 years * BMI ≤ 35 kg/m2 Exclusion Criteria: * Patients with a pre-existing neuropathy or sensory deficit affecting the operative region * Pregnancy * Chronic pain or opioid dependence (at least 30 mg of oxycodone or equivalent per day) * Allergy to local anaesthesia or any component of the proposed multimodal analgesia regimen * Local or systemic contra-indications to peripheral nerve blocks (local infection at the puncture site, coagulopathy, platelets less than 80\*10\^9/L and prothrombin time more than 15 s)
References
Publications (1)
- DERIVEDXu J, Ling D, Xu Q, Sun P, Wei S, Gao L, Lou F, Zhang J. Ultrasound-Guided Double-Point Versus Single-Point Serratus Anterior Plane Block for Modified Radical Mastectomy: A Randomized Controlled Trial. Clin J Pain. 2025 Jan 1;41(1):e1256. doi: 10.1097/AJP.0000000000001256. PMID 39475834