Clinical trial · Observational
High-power Green-light Laser Endoscopic Submucosal Dissection for Non-muscle-invasive Bladder Cancer
High-power Green-light Laser Endoscopic Submucosal Dissection for Non-muscle-invasive Bladder Cancer: a Technical Improvement and Its Initial Application
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
A retrospective study was designed in this study. The surgeon performed high-power green-light laser endoscopic submucosal dissection (HPL-ESD) for the treatment of primary non-muscle-invasive bladder cancer (NMIBC). This surgical treatment was novel and safety and efficacy of the treatment has not been established. We collected relative data in Shandong Provincial Hospital Affiliated to Shandong First Medical University from May 2018 to December 2020. Preoperative, intraoperative and postoperative clinical data were collected and analysed. The safety and efficacy of the novel surgical treatment were verified by the short-term and long-term clinical outcomes. Fifty patients with NMIBC were planed to be enrolled in the study.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Bladder Cancer | Malignant Bladder Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Success rate of the surgery
- timeFrame
- after all data has been collected, analysis will be finished within 5 days
- description
- The success of the surgery was NMIBC got en bloc resection by HPL-ESD without transfering to other treatment. Success rate of the surgery is the proportion of surgery success in all surgery.
Secondary outcomes (7)
- measure
- Rate of tumor en bloc resection
- timeFrame
- after all data has been collected, analysis will be finished within 5 days
- description
- The proportion of tumor en bloc resection (R0 resection) in all resected tumors.
- measure
- Operative time
- timeFrame
- after all data has been collected, analysis will be finished within 5 days
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 88 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with non-muscle invasive bladder cancer who received high-power green laser submucosal resection of bladder tumor Exclusion Criteria: * Patients with muscle invasive bladder cancer * Patients with recurrent bladder cancer * Patients with benign bladder tumor
References
Publications (16)
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- BACKGROUNDZhu Y, Jiang X, Zhang J, Chen W, Shi B, Xu Z. Safety and efficacy of holmium laser resection for primary nonmuscle-invasive bladder cancer versus transurethral electroresection: single-center experience. Urology. 2008 Sep;72(3):608-12. doi: 10.1016/j.urology.2008.05.028. Epub 2008 Jul 23. PMID 18649930
- BACKGROUNDNagele U, Kugler M, Nicklas A, Merseburger AS, Walcher U, Mikuz G, Herrmann TR. Waterjet hydrodissection: first experiences and short-term outcomes of a novel approach to bladder tumor resection. World J Urol. 2011 Aug;29(4):423-7. doi: 10.1007/s00345-011-0653-8. Epub 2011 Feb 9. PMID 21305303
- BACKGROUNDHerrmann TR, Wolters M, Kramer MW. Transurethral en bloc resection of nonmuscle invasive bladder cancer: trend or hype. Curr Opin Urol. 2017 Mar;27(2):182-190. doi: 10.1097/MOU.0000000000000377. PMID 28033148
- BACKGROUNDFried NM, Murray KE. High-power thulium fiber laser ablation of urinary tissues at 1.94 microm. J Endourol. 2005 Jan-Feb;19(1):25-31. doi: 10.1089/end.2005.19.25. PMID 15735378
- BACKGROUNDHe D, Fan J, Wu K, Wang X, Wu D, Li L, Li X, Liu L, Cao P, Cao J, Chang LS. Novel green-light KTP laser en bloc enucleation for nonmuscle-invasive bladder cancer: technique and initial clinical experience. J Endourol. 2014 Aug;28(8):975-9. doi: 10.1089/end.2013.0740. Epub 2014 May 19. PMID 24735433
- BACKGROUNDTao W, Yang D, Shan Y, Xue B, Sun C, Zang Y, Zhang Y. Safety and efficacy of 120W high performance system greenlight laser vaporization for non-muscle-invasive bladder cancer. J Xray Sci Technol. 2013;21(2):309-16. doi: 10.3233/XST-130379.