Clinical trial · Interventional
DAHANCA 27 Transoral Laser Microsurgery for T1a Glottic Cancer
NCT05289336CI-TRIAL-00057230DAHANCA 27unknownPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To evaluate whether Transoral Laser Microsurgery (TLM) is non-inferior compared to Accelerated Radiotherapy (accRT) in the treatment of T1aN0M0 glottic SCC
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Glottic T1 | — | UNRESOLVED | — |
| Head and Neck Squamous Cell Carcinoma | Head and Neck Squamous Cell Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Transoral Laser Microsurgery | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Transoral Laser Microsurgery
- description
- Transoral Laser Microsurgery
- interventionNames
- Procedure: Transoral Laser Microsurgery
Primary outcomes (1)
- measure
- laryncegtomy free survival
- timeFrame
- 5 years
- description
- Alive with larynx
Secondary outcomes (6)
- measure
- Local control
- timeFrame
- 5 years
- description
- Free from disease after primary treatment
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Danish patients aged ≥18 years diagnosed with a T1aN0M0 glottic squamous cell carcinoma (SCC) Exclusion Criteria: * Unable to complete curative intended protocol treatment and/or planned follow up * informed concent
References
Publications (1)
- DERIVEDLyhne NM, Kjaergaard T, Tvedskov JF, Godballe C, Hald K, Ulhoi BP, Printz T, Overgaard J. The DAHANCA 27 Phase II Study: Transoral Laser Microsurgery for T1aN0M0 Glottic Squamous Cell Carcinoma, a Comparison to Accelerated Radiotherapy. Head Neck. 2025 Dec;47(12):3228-3236. doi: 10.1002/hed.28225. Epub 2025 Jul 7. PMID 40622110