Clinical trial · Observational
Desmoid Tumor and Pregnancy: Effect of Pregnancy on Disease Control and Effect of Diagnosis on Pregnancy History.
Desmoid Tumor and Pregnancy: Effect of Pregnancy on Disease Control and Effect of Diagnosis on Pregnancy History. An International Multicenter Retrospective Observational Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Desmoid tumors (DT) are rare disease of intermediate malignancy with variable and often unpredictable clinical course. There is a growing interest in defining potential risk of recurrence or progression during or after pregnancy and in identifying potential obstetrical risks and infertility rate of desmoid patients. Aim of the study: * to define the impact of pregnancy on diagnosis, progression and recurrence of DT; * to define the risks related to DT of obstetrical risks and decisions to interrupt or avoid pregnancy after the diagnosis of DT.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Desmoid | — | UNRESOLVED | — |
| Desmoid; Abdominal | — | UNRESOLVED | — |
| Pregnancy Complications | — | UNRESOLVED | — |
| Pregnancy Loss | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Pregnancy | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Patients with history of pregnancy
- description
- Patients with DT diagnosed during pregnancy; patients with DT with macroscopic disease in situ at the time of pregnancy (including previous partial resection, recurrent disease, primary disease followed with active surveillance); resected DT without clinical evidence of residual or recurrent disease at the onset of pregnancy.
- interventionNames
- Other: Pregnancy
- label
- Patients without history of pregnancy
- description
- Patients with DT without history of pregnancy
Primary outcomes (2)
- measure
- Proportion of new disease progression during pregnancy Progression disease according to RECIST within 1 year after delivery in patients with previous stable disease. Proportion of new disease progression during pregnancy
- timeFrame
- January 2000- December 2020
- description
- Progression disease according to RECIST within 1 year after delivery in patients with previous stable disease.
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * histologically-proven DT; * female patients * fertile age, \>18 years; * concomitant or subsequent pregnancy (study group), or no history of pregnancy (screening group). Exclusion Criteria: * suspected DT without histological diagnosis • male patients affected by DT * \<18 years old, and non-fertile age.
References
Publications (0)
Data not yet available