Clinical trial · Observational
Effect Analysis of Neoadjuvant Chemoradiotherapy Combined With Surgery in Laparoscope for Advanced Colon Cancer
Effect Analysis of Neoadjuvant Chemoradiotherapy Combined With Radical Surgery ( CME + D3 ) for Advanced Colon Cancer : Prospective, a Single-arm, Single Central, Clinical Trial Research
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In this study, a randomized controlled trial was conducted on advanced colon cancer patients with preoperative tumor staging T1-4/N1-2/M0 or T4/N0/M0 to determine the effectiveness of preoperative short-term radiotherapy combined with chemotherapy and whether it can effectively reduce the postoperative local recurrence rate, so as to provide better treatment for colon cancer patients and improve the oncological treatment effect of colon cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colon Neoplasm | Colon Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Short-term neoadjuvant chemoradiotherapy | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- neoadjuvant chemoradiotherapy group
- description
- preoperative 1 circle chemotherapy(CapeOX) combined with short-course radiotherapy ，Surgical treatment(CME+D3) after four weeks of 2 circle chemotherapy(CapeOX).
- interventionNames
- Radiation: Short-term neoadjuvant chemoradiotherapy
- label
- neadjuvant chemotherapy group
- description
- preoperative 3 circle chemotherapy(CapeOX) combined with surgical treatment(CME+D3)
Primary outcomes (1)
- measure
- Investigate patients ORR
- timeFrame
- 7 days after surgery
- description
- Investigate patients ORR(objective response rate ) include CR(complete response) and PR(partial response)
Secondary outcomes (6)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosis of colon neoplasm * 18 years to 70 years * Preoperative abdominal enhanced CT or MRI showed cT4, cN0-2 * ECOGS score≤2 * thoraco-abdomina CT showed no obvious metastasis（The CT of liver and lung show uncertainty tubercle,suggestive performed PET-CT) cT4,cN0-2,M0 radiography Inclusion Criteria（according postoperative enhanced CT or MRI） * progress tubercle penetrate peritoneotome base * progress tubercle penetrate serous surface of neighboring organ * progress tubercle development by late mesentery or side abdominis Exclusion Criteria: * Appeared other system cancer * Patient with postoperative recurrent of colon cancer * Patient with malignancies history in recent 5 years * Pregnant or female of suckle period * The patient have adjuvant radiotherapy record in other system cancer before this time treatment，and Patient with surgical contraindications. * The patient have accepted adjuvant chemoradiotherapy before this time treatment. * Distant metastasis found during surgery * Patients with poor radiotherapy compliance and difficulty in coordination * Patients with mental disorders
References
Publications (0)
Data not yet available