Clinical trial · Interventional
The Impact of Choice on Colorectal Cancer Screening
The Impact of Choice on Colorectal Cancer (CRC) Screening Uptake Among Average-risk Individuals 45-49 Years of Age
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In May of 2021, the United States Preventive Service Task Force (USPSTF) updated their colorectal cancer (CRC) screening guidelines by recommending screening at an earlier age for average-risk adults starting at the age of 45 years old (Grade B recommendation). This is in addition to their Grade A recommendations of continuing to screen average-risk adults ages 50-75 years old. UCLA Health previously implemented a fecal immunochemical test (FIT) outreach program wherein FIT kits are mailed to average-risk patients overdue for CRC screening twice annually to promote screening uptake. As the investigators health system aims to screen the newly eligible population of average-risk patients between the ages of 45-49, the investigators proposed randomized controlled trial is aimed to determine the most effective patient outreach approach to maximize screening uptake within this age-group.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Colorectal Neoplasms | Colorectal Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Health Screening | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Active Colonoscopy Choice | Behavioral | — | UNRESOLVED |
| Active Dual Choice | Behavioral | — | UNRESOLVED |
| Active FIT Choice | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- NO_INTERVENTION
- label
- Standard of Care
- description
- No Intervention-"Standard Care" UCLA Health has a mailed FIT outreach program. This group will receive standard FIT mailer protocol. They will receive a tailored MyChart message indicating the importance of CRC screening and not be presented with a choice for screening modalities.
- type
- EXPERIMENTAL
- label
- FIT Choice
- description
- This group will receive a tailored message via MyChart with information about CRC screening and using the FIT kit for noninvasive screening. They will then have to actively choose if they want CRC screening with a FIT kit vs no screening. If they opt for screening, the investigators will mail them a FIT kit.
- interventionNames
- Behavioral: Active FIT Choice
- type
- EXPERIMENTAL
- label
- Colonoscopy Choice
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 45 Years
- Maximum age
- 49 Years
Show eligibility criteria text
Inclusion Criteria * UCLA Health patient * Age 45-49 (as of 1/1/2022) * Active primary care provider at UCLA Health * Visit within the last 3 years Exclusion Criteria * Age \<45 or \>50 years old at time of randomization * Documented family history of CRC in EMR * History (personal or family) of prior adenomatous polyps in the EHR * History of high-risk cancer syndromes (e.g., Lynch, FAP) * Prior CRC screening with colonoscopy or FIT * Inactive MyChart status at enrollment * No documented SMS-capable phone number
References
Publications (1)
- DERIVEDGaloosian A, Dai H, Croymans D, Saccardo S, Fox CR, Goshgarian G, De Silva S, Han MA, Vangala S, May FP. Population Health Colorectal Cancer Screening Strategies in Adults Aged 45 to 49 Years: A Randomized Clinical Trial. JAMA. 2025 Sep 2;334(9):778-787. doi: 10.1001/jama.2025.12049. PMID 40758331