Clinical trial · Observational
Preoperative Immunonutrition in Laparoscopic Total D2 Gastrectomy
Preoperative Immunonutrition in Laparoscopic Total D2 Gastrectomy: a Single-centre Comparative Study
NCT05259488CI-TRIAL-00056789completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Immunonutrition (IN) appears to reduce infective complications and in-hospital length of stay (LOS) after gastrointestinal surgery. More specifically, it seems to be beneficial also in gastric cancer surgery. Potential benefits of combining preoperative IN (PIN) with protocols of enhanced recovery after surgery (ERAS) in reducing LOS in laparoscopic total gastrectomy are yet to be determined.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Digestive Cancer | Digestive System Neoplasm | PROBABILISTIC | 0.70 |
| Gastric Cancer | Malignant Gastric Neoplasm | CURATED_BROADER | 0.80 |
| Gastric Neoplasm | Gastric Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Laparoscopic | — | UNRESOLVED | — |
| Surgery | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| immunonutrition | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- patients receiving immunonutrition supply
- description
- Dietary Supplement: Immunonutrition nutridrinks 3 times a day 5 days prior surgery plus maltodextrins the day of surgery
- interventionNames
- Dietary Supplement: immunonutrition
- label
- historical control group
- description
- standard dietary advice
Primary outcomes (2)
- measure
- 30-days postoperative complications
- timeFrame
- up to 30 days after discharge
- description
- Rate of any complication after colorectal resection
- measure
- LOS
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age \>18 years * Primary gastric cancer * Preoperative staging I-III * Eligible for laparoscopic D2 total gastrectomy Exclusion Criteria: * Acquired or congenital immunodeficiency * Malnutrition (MNA-SF score \< 12) * Preoperative infection * Previous gastric surgery * ASA IV * Emergency setting * Para-aortic node involvement * Intraoperative evidence of distant metastasis or peritoneal carcinosis * Conversion to open surgery
References
Publications (1)
- DERIVEDFranceschilli M, Siragusa L, Usai V, Dhimolea S, Pirozzi B, Sibio S, Di Carlo S. Immunonutrition reduces complications rate and length of stay after laparoscopic total gastrectomy: a single unit retrospective study. Discov Oncol. 2022 Jul 11;13(1):62. doi: 10.1007/s12672-022-00490-5. PMID 35816241