Clinical trial · Observational
COr Loco-regional Advanced Lung Cancer Treated With Chemo-radiotherapy (COLA)
The Effect of Radiotherapy on the Heart in Loco-regional Advanced NSCLC Patients Treated With Definitive Radiotherapy Measured by Cardiac MR
NCT05258448CI-TRIAL-00072030COLArecruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Patients with loco-regional NSCLC planned for curative treatment with chemoradiotherapy will be invited to participate in a prospective study; besides routine treatment, the patients will be followed with an ECG and cardiac MR for at least two years after radiotherapy treatment.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cardiac Disease | — | UNRESOLVED | — |
| Cardiac Toxicity | — | UNRESOLVED | — |
| Lung Cancer Stage II | Malignant Lung Neoplasm | CURATED_BROADER | 0.78 |
| Lung Cancer Stage III | Malignant Lung Neoplasm | CURATED_BROADER | 0.78 |
| Radiation Toxicity | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Chemoradiotherapy | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- COLA 1: Locally advanced non-small-cell lung cancer
- description
- Patients with locally advanced non-small-cell lung cancer treated with radiotherapy alone or in combination with chemotherapy with curative intent. Patients are included before initiation of the treatment. A Cardiac MR and ECG are performed at the beginning of the treatment, and at 6, 12, and 24 months after radiotherapy.
- interventionNames
- Other: Chemoradiotherapy
- label
- COLA 2 Locally advanced non-small-cell lung cancer
- description
- Patients with locally advanced non-small-cell lung cancer treated with radiotherapy alone or in combination with chemotherapy with curative intent. Patients not included in COLA 1 cohort are offered one cardiac MR and ECG between 12-24 months after radiotherapy treatment.
- interventionNames
- Other: Chemoradiotherapy
Primary outcomes (4)
- measure
- Overall survival
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age ≥ 18 Years * Inoperable and histologically/cytologically verified NSCLC. * Planned treatment with curative intent. * Capable of completing study procedures ECG and Cardiac MR. * Able of giving written and informed consent before study procedures are initiated. Exclusion Criteria: * Vulnerable patients. * Patients with operable devices as pacemaker/ICD and cochlear implant or other conditions where MR scan is contraindicated. * Claustrophobia.
References
Publications (0)
Data not yet available
No reference posted for this study.