Clinical trial · Interventional
Plasma-free Replacement in Patients With Multiple Myeloma
An Efficient Method of Eliminating M Protein in Patients With Multiple Myeloma by Plasma-free Replacement
NCT05251896CI-TRIAL-00068006completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To evaluate whether the technique of no plasma exchange is suitable for the treatment, clinical efficacy, safety, and suitability of multiple myeloma patients with M protein abnormality or renal failure.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Multiple Myeloma | Multiple Myeloma | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Plasma-free procedure | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Plasma-free procedure
- description
- Use albumin solution, lactated Ringer's solution, normal saline as replacement fluid
- interventionNames
- Procedure: Plasma-free procedure
Primary outcomes (17)
- measure
- Change from M protein content in plasma at Week 18
- timeFrame
- Day 0，Day 1，Week 1，Week4，Week 12，Week 18
- description
- M protein content in plasma
- measure
- Change from Blood routine in plasma at Week 18
- timeFrame
- Day 0，Day 1，Week 1，Week4，Week 12，Week 18
- description
- WBC
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1\. Clinical diagnosis of MM 2. A stable condition after routine treatment 3. Clinical diagnosis of renal insufficiency or M protein abnormalities 4．more than 18 years old 5．With liver and kidney function 6. With normal heart function; 7. Physical condition score 0-2 (ECOG score) 8. Get informed consent from the patient or family member. Exclusion Criteria: 1. Allergies or obvious contraindications to any drug; 2. Myocardial infarction and cardiac insufficiency 3. Other malignant tumors 4. TB patients and HIV positive patients 5．Other blood system diseases 6\. Pregnant or lactating women; 7. Not understand or follow the protocol; 8. Allergy
References
Publications (0)
Data not yet available
No reference posted for this study.