Clinical trial · Observational
English Mammography Screening Outcomes by Age, Frequency and Test Threshold
Observational Study of Age, Test THreshold and Frequency on English NAtional Mammography Screening Outcomes (ATHENA-M)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Breast cancer screening involves taking mammograms (x-rays) of women's breasts to search for signs of cancer. This study investigates the impact of test threshold, screening interval (frequency) and age of eligibility on intermediate outcomes, and health outcomes such as mortality and morbidity. This observational study links breast cancer screening, cancer registry and mortality registration data to answer these questions.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Increase in upper age of eligibility for breast cancer screening from 64 to 70 | Other | — | UNRESOLVED |
| Screening round length | Other | — | UNRESOLVED |
| Screening test threshold | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Women invited to Breast Cancer Screening in England
- description
- Women invited to Breast Cancer Screening in England up to 31st March 2018
- interventionNames
- Other: Increase in upper age of eligibility for breast cancer screening from 64 to 70
- label
- Women attending Breast Cancer Screening in England
- description
- Women attending mammography screening to examine the effect of screening test threshold on outcomes, up to 31st March 2018
- interventionNames
- Other: Screening round length
- Diagnostic Test: Screening test threshold
Primary outcomes (12)
- measure
- Breast Cancer Specific Mortality
- timeFrame
- Cumulative incidence of breast cancer specific mortality over all follow-up time (up to maximum 30 years)
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 47 Years
- Maximum age
- 73 Years
Show eligibility criteria text
Inclusion Criteria: * Women invited for breast cancer screening by the English NHS Breast Screening Programme Exclusion Criteria: * Missing or corrupted data for NHS number, so linkage between databases is not possible * For analysis of test threshold and screening interval: women who did not attend routine English NHS Breast screening service within the specified date and age range, even if they attended symptomatic breast cancer services, high risk (family history) breast screening services, or if they were referred for mammograms by their general practitioner
References
Publications (0)
Data not yet available