Clinical trial · Interventional
A Study to Evaluate the Safety and Pharmacokinetics of XMAB24306 in Combination With Daratumumab in Participants With Relapsed/Refractory Multiple Myeloma
A Phase Ib, Open-Label, Multicenter, Dose-Escalation Study to Evaluate the Safety and Pharmacokinetics of XMAB24306 in Combination With Daratumumab in Patients With Relapsed/Refractory Multiple Myeloma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study will evaluate the safety, tolerability, pharmacokinetics, and activity of XmAb24306 in combination with a multiple myeloma (MM)-targeting monoclonal antibody capable of inducing antibody-dependent cellular toxicity (ADCC) in participants with relapsed or refractory (R/R) MM who have received a minimum of three prior treatments, including at least one immunomodulatory drug (IMiD), one proteasome inhibitor (PI), and one anti-CD38 monoclonal antibody.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Multiple Myeloma | Multiple Myeloma | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Daratumumab | Drug | Daratumumab | ALIAS |
| XmAb24306 | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Dose escalation
- description
- Participants will receive escalating doses of XmAb24306 with daratumumab up to the maximum tolerated dose (MTD)
- interventionNames
- Drug: XmAb24306
- Drug: Daratumumab
- type
- EXPERIMENTAL
- label
- Dose expansion
- description
- Participants will receive XmAb24306 with daratumumab at the recommended phase 2 dose (RP2D)
- interventionNames
- Drug: XmAb24306
- Drug: Daratumumab
Primary outcomes (1)
- measure
- Percentage of participants with adverse events (AEs)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Life expectancy of at least 12 weeks * Measurable disease, as defined by the protocol * Participants must have received a minimum of 3 prior lines of therapy, including at least one PI, one IMiD, and an anti-CD38 monoclonal antibody * Best response of stable disease or better with at least one prior anti-CD38 monoclonal antibody containing line of treatment Exclusion Criteria: * Any anti-cancer therapy within 3 weeks prior to initiation of study treatment, with exceptions defined by the protocol * Prior allogeneic stem cell or solid organ transplantation * Autologous stem cell transplantation within 100 days prior to initiation of study treatment * Significant cardiovascular disease * Known clinically significant liver disease * Active or history of autoimmune disease or immune deficiency * Known active infection requiring IV anti-microbial therapy within 14 days prior to first study drug administration * Primary or secondary plasma cell leukemia * Current CNS involvement by MM * Other protocol defined inclusion/exclusion criteria may apply
References
Publications (0)
Data not yet available