Clinical trial · Observational
Imaging Sodium and Lymphatics in Lymphedema
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Recent evidence supports lymphatic regulation of tissue sodium handling, however fundamental gaps persist in knowledge regarding the role of lymphatics in human diseases of sodium dysregulation. The goal of this work is to apply novel, noninvasive imaging tools to measure relationships between lymphatic function and tissue sodium in patients with well-characterized lymphedema. Findings are intended to inform mechanisms of lymphatic clearance of tissue sodium, and provide novel imaging biomarkers of lymphedema progression and treatment response.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lymphedema of Leg | — | UNRESOLVED | — |
| Lymphedema Related Fibrosis | — | UNRESOLVED | — |
| Lymphedema, Secondary | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Complete decongestive therapy | Procedure | — | UNRESOLVED |
| Standard imaging protocol | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- At-risk for lymphedema
- description
- Participants at-risk for leg lymphedema
- interventionNames
- Other: Standard imaging protocol
- label
- With lymphedema
- description
- Participants with leg lymphedema
- interventionNames
- Other: Standard imaging protocol
- label
- With lymphedema undergoing complete decongestive therapy (CDT)
- description
- Participants with leg lymphedema undergoing routine complete decongestive therapy (CDT)
- interventionNames
- Procedure: Complete decongestive therapy
- Other: Standard imaging protocol
Primary outcomes (4)
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Biologically Female * Age range = 18-80 years * BMI range = 18 to 40 kg/m2 Exclusion Criteria: * Primary lymphedema * Contraindication to 3T MRI * Pregnant * Severe claustrophobia * Inability to provide written, informed consent * Active infection anywhere in the body, or open wound on the lower-extremities or at locations for measurement * Subjects who cannot adhere to the experimental protocols for any reason
References
Publications (0)
Data not yet available