Study to Evaluate the Efficacy and Safety of Tenalisib, Given With CHOP Therapy for Front Line Treatment in Patients With PTCL

Inclusion Criteria:

1. Provision of full informed consent prior to any study-specific procedures.
2. Pathologically confirmed diagnosis of PTCL according to WHO 2016 classification criteria EXCEPT following subtypes:

   * ALK-positive anaplastic T-cell lymphoma; CD30+ PTCL (who are eligible for BV and CHOP combination); extra-nodal NK/T-cell lymphoma, nasal type; HTLV1- associated lymphoma; primary cutaneous anaplastic T-cell lymphoma, T-cell lymphoma with only skin involvement
3. Disease status is defined as treatment naïve patients with PTCL who have not received prior systemic therapy for lymphoma.
4. Must have ECOG performance status ≤ 2
5. Patients must have measurable disease defined as at least one bi-dimensional measurable lesion assessed radiologically with a minimum measurement of \> 1.5 cm in the longest diameter.
6. Patients must be fit to receive full-dose CHOP Therapy.
7. Adequate bone marrow, liver and renal functions

Exclusion Criteria:

1. Patients who have received prior systemic therapy for lymphoma or are receiving anticancer therapy including any investigational therapy (e.g., chemotherapy, biologic therapy, hormonal therapy).
2. Patients with known Central Nervous System (CNS) lymphoma or CNS involvement by lymphoma.
3. Active uncontrolled systemic fungal, bacterial or viral infection
4. Patient with ongoing or significant cardiac disease in last 6 months which according to the investigator can impact study participation
5. Patients with co-morbidities/complications
6. Known history of severe liver injury/disease
7. Active viral infection with human immunodeficiency virus (HIV), hepatitis B, or hepatitis C. and history of severe cutaneous reactions
8. Patient with any other active malignancy at the time of screening except for adequately treated in situ carcinoma of the cervix uteri or carcinoma in situ of breast, basal cell carcinoma of the skin or localized squamous cell carcinoma of the skin,
9. Hypersensitivity to the active substance or to any of the excipients.
10. Pregnancy or lactation.
11. Concurrent medications or substance, the example of these treatment includes strong inhibitors or inducer of CYP3A4 enzyme or substrate of CYP3A4 with narrow therapeutic index.