Clinical trial · Interventional
Prevalence of the c.853delT Mutation of the HOXB13 Gene in Prostate Cancer in Martinique
NCT05231915CI-TRIAL-00106871HOXB13_MartcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In Martinique, prostate cancer incidence rates are nowadays among the highest worldwide with a high incidence of early-onset and familial forms. We identified a rare heterozygous germline variant c.853delT (p.Ter285Lysfs) rs77179853, reported only among patients of African ancestry with a minor allele frequency of 3.2%. We search to estimate the prevalence of this variant in a sample of prevalent prostate cancer cases managed in urology consultation in Martinique .
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| HOXB13 c.853delT mutation | Genetic | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- HOXB13 c.853delT mutation
- description
- Mutation is detected using Next Generation Sequencing (NGS) technique
- interventionNames
- Genetic: HOXB13 c.853delT mutation
Primary outcomes (1)
- measure
- Estimation of prevalence of Allelic frequency of the HOXB13 c.853delT mutation
- timeFrame
- At baseline
- description
- Mutation is detected using Next Generation Sequencing (NGS) technique
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adult man over 18 years of age living in Martinique with a prostate cancer whatever the histological type and the stage, managed in urology consultation (public and private sectors of Martinique) * Sporadic or familial form * Informed with a written consent signed by the participant and the investigator * Affiliate or beneficiary of french social security. Exclusion Criteria: * Patient who is not of African descent * Refusal to participate. * Patients not affiliated to french social security
References
Publications (0)
Data not yet available
No reference posted for this study.