Clinical trial · Interventional
Pituitary Gland Stimulation for Cancer Pain Relief
NCT05230238CI-TRIAL-00064619PGSunknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Patients will undergo an implantation of an extradural pituitary surface electrode in the pituitary fossa. The electrode will be attached to a neurostimulator via which the patient will receive up to 8 (patient requested) stimulations per day.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Oncology Pain | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Pituitary gland stimulation | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- pituitary stimulation
- description
- Patients will receive pituitary stimulation as oncology pain treatment.
- interventionNames
- Device: Pituitary gland stimulation
Primary outcomes (2)
- measure
- Perceived pain
- timeFrame
- 4 months
- description
- Numeric Rating Scale (0= no pain, 10=most severe pain)
- measure
- Pain Medication
- timeFrame
- 4 months
- description
- Morphine Equivalent Doses for background and escape medication
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adult patient * In palliative phase of metastatic disease, without options for further systemic treatment or radiotherapy * Inadequately controlled pain with standard care * Most prominent part of experienced pain is nociceptive * Karnofsky Performance Score ≥30 Exclusion Criteria: * Not fit for general anesthesia * Pregnancy * Unfavorable local anatomy for PGS, due to a disease process, or anatomical configuration * Clinical signs of posterior pituitary gland disfunction * Recent history of alcohol or drug abuse * Severe immunodeficiency * Need for anticoagulation therapy that cannot be abrogated for surgery * Need for subsequent MRI-imaging * Cognitive impairments prohibiting full understanding of study and ability to provide informed consent * Not able to adequately communicate in Dutch or English
References
Publications (0)
Data not yet available
No reference posted for this study.