Clinical trial · Interventional
Nurse AMIE (Addressing Malignancies in Individuals Everyday)
NCT05221606CI-TRIAL-00105068active not recruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Nurse AMIE 3.0 is testing the effectiveness of an electronic symptom management system on overall survival in people with stage 3 and 4 cancer who live in rural areas.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Nurse AMIE | Behavioral | — | UNRESOLVED |
| Usual Care | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Nurse AMIE Supportive Care Intervention
- description
- Participants in the intervention arm will receive the computer tablet with the Nurse AMIE program. Nurse AMIE will assess their symptoms daily and provide an intervention to help manage their symptoms.
- interventionNames
- Behavioral: Nurse AMIE
- type
- ACTIVE_COMPARATOR
- label
- Usual Care
- description
- Participants in the usual care arm will receive a book with some supportive care educational materials and recommendations.
- interventionNames
- Behavioral: Usual Care
Primary outcomes (1)
- measure
- Survival
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patient receiving care for their cancer 2. Age: 18+ years of age 3. Has stage 3 or 4 cancer, or an unstaged cancer that is considered 'advanced' (greater than stage 2) by their treating oncologist 4. Must be within six months of initiation of pharmacologic or radiation treatment, for curative or palliative purposes, from a medical or radiation oncologist 5. Clinician-rated ECOG function of 0-3 6. Lives in a county with RUCC code 4 - 9 and/or zip code with RUCA code 4-10 7. Has access to personal device capable of receiving telephone calls for study facilitator check-ins 8. Fluent in written and spoken English 9. Sufficient vision/hearing to interact with the tablet and study staff 10. Clinician-defined life expectancy of 6 months or more Exclusion Criteria: 1. Patients with medical or psychiatric conditions documented in the medical record (beyond cancer, its treatments, and its symptoms) that would impair our ability to test study hypotheses (e.g. psychotic disorders, dementia, inability to give informed consent, or follow study instructions). 2. Patients who are participating in any other supportive care or behavioral intervention studies. 3. Non-English speaking patients will be excluded, as they represent less than 2% of the population targeted.
References
Publications (2)
- DERIVEDSchmitz KH, Baker S, Ahmed M, Celebre R, Patterson CG, Smith C, Werts-Pelter SJ, Stout N, Moss J, Calo WA, Sobolewski M, Doerksen SE. Worse Function and Symptoms Among the Most Rural Patients With Advanced Cancer: A Cross-Sectional Analysis. Cancer Med. 2026 Jun;15(6):e72033. doi: 10.1002/cam4.72033. PMID 42286931
- DERIVEDSchmitz KH, Baker S, Werts-Pelter SJ, Doerksen S, Patterson CG, Ahmed M, Scalise R, Vincent A, Desroches C, Sobolewski M, Celebre R, Garrett S, Stout N, Calo WA, Fisher S, Schleicher E, Gordon B, Kumar P. Nurse AMIE randomized controlled trial to address symptom management among rural advanced Cancer patients: Addressing malignancies in everyday life. Contemp Clin Trials. 2025 Aug;155:108005. doi: 10.1016/j.cct.2025.108005. Epub 2025 Jul 10. PMID 40651555