Clinical trial · Observational
Oral Antibiotic Bowel Preparation in Gynecologic Oncology Surgery
NCT05210556CI-TRIAL-00087810completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to investigate whether the use of a preoperative antibiotic bowel regimen is associated with a reduced risk of deep organ/space surgical site infection in gynecologic oncology surgery.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gynecologic Cancer | Malignant Female Reproductive System Neoplasm | ALIAS | 0.90 |
| Surgical Complication | — | UNRESOLVED | — |
| Surgical Site Infection | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Diagnosed with Surgical Site Infection | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- No Antibiotic Bowel Prep
- description
- Patients who did not receive a preoperative antibiotic bowel preparation
- interventionNames
- Other: Diagnosed with Surgical Site Infection
- label
- Antibiotic Bowel Prep
- description
- Patients who did receive a preoperative antibiotic bowel preparation
Primary outcomes (1)
- measure
- Surgical Site Infection Rates Associated with Antibiotic Bowel Prep
- timeFrame
- 2019-2021
- description
- Rate of surgical site infection rate as associated with or without use of antibiotic bowel preparation
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 99 Years
Show eligibility criteria text
Inclusion Criteria: \- Underwent scheduled intra-abdominal surgery with a WellSpan gynecologic oncologist Exclusion Criteria: * Unscheduled surgery * Intraoperative consult by a WellSpan gynecologic oncologist
References
Publications (5)
- BACKGROUNDNelson RL, Glenny AM, Song F. Antimicrobial prophylaxis for colorectal surgery. Cochrane Database Syst Rev. 2009 Jan 21;(1):CD001181. doi: 10.1002/14651858.CD001181.pub3. PMID 19160191
- BACKGROUNDMorris MS, Graham LA, Chu DI, Cannon JA, Hawn MT. Oral Antibiotic Bowel Preparation Significantly Reduces Surgical Site Infection Rates and Readmission Rates in Elective Colorectal Surgery. Ann Surg. 2015 Jun;261(6):1034-40. doi: 10.1097/SLA.0000000000001125. PMID 25607761
- BACKGROUNDKalogera E, Van Houten HK, Sangaralingham LR, Borah BJ, Dowdy SC. Use of bowel preparation does not reduce postoperative infectious morbidity following minimally invasive or open hysterectomies. Am J Obstet Gynecol. 2020 Aug;223(2):231.e1-231.e12. doi: 10.1016/j.ajog.2020.02.035. Epub 2020 Feb 26. PMID 32112733
- BACKGROUNDNichols RL, Broido P, Condon RE, Gorbach SL, Nyhus LM. Effect of preoperative neomycin-erythromycin intestinal preparation on the incidence of infectious complications following colon surgery. Ann Surg. 1973 Oct;178(4):453-62. doi: 10.1097/00000658-197310000-00008. No abstract available. PMID 4743867
- DERIVEDKennedy K, Gaertner-Otto J, Lim E. Reduction in deep organ-space infection in gynecologic oncology surgery with use of oral antibiotic bowel preparation: a retrospective cohort analysis. J Osteopath Med. 2024 Oct 9;125(5):269-276. doi: 10.1515/jom-2024-0099. eCollection 2025 May 1. PMID 39376031