Clinical trial · Interventional
Interventions in Mathematics and Cognitive Skills
Interventions in Math Learning Disabilities: Cognitive and Neural Correlates
NCT05201534CI-TRIAL-00121424recruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning disabilities (MLD).
Conditions
Conditions (28)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Behavior | — | UNRESOLVED | — |
| Behavior and Behavior Mechanisms | — | UNRESOLVED | — |
| Behavior, Child | — | UNRESOLVED | — |
| Child Development | — | UNRESOLVED | — |
| Cognition | — | UNRESOLVED | — |
| Cognition Disorder | — | UNRESOLVED | — |
| Cognitive Abnormality | — | UNRESOLVED | — |
| Cognitive Change | — | UNRESOLVED | — |
| Cognitive Deficits, Mild | — | UNRESOLVED | — |
| Cognitive Delay, Mild | — | UNRESOLVED | — |
| Cognitive Developmental Delay | — | UNRESOLVED |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Interventions in Mathematics and Cognitive Skills - Active Comparator | Other | — | UNRESOLVED |
| Interventions in Mathematics and Cognitive Skills - Experimental | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Integrative Symbolic Non-Symbolic (iSNS) Training
- description
- Integrative symbolic non-symbolic (iSNS) training: Over a period of 6 weeks, participants will complete activities that progressively strengthen the mapping of symbolic numerical representations to non-symbolic numerical quantities and enhance fluency in symbolic numerical skills.
- interventionNames
- Other: Interventions in Mathematics and Cognitive Skills - Experimental
- type
- ACTIVE_COMPARATOR
- label
- Active Comparator: Active Control Intervention (Working Memory Training)
- description
- Active control intervention: Over a period of 6 weeks, participants will complete activities that enhance short-term storage and maintenance of visuospatial or verbal information.
- interventionNames
- Other: Interventions in Mathematics and Cognitive Skills - Active Comparator
Primary outcomes (10)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 6 Years
- Maximum age
- 12 Years
Show eligibility criteria text
Inclusion Criteria: 1. Elementary school aged children starting from first grade (6-12 years old) 2. IQ: Participants with a Full Scale IQ \> 70 on the Wechsler Abbreviated Scle of Intelligence (WASI-II). 3. Identification of Mathematical Learning Disabilities: Scores below the 35th percentile percentile on symbolic number processing test in Numeracy Screener and two or more Wechsler Individual Achievement Test (WIAT-IV) math subtests 4. Identification of typically developing children: Scores at or above the 35th percentile percentile on symbolic number processing test in Numeracy Screener and all WIAT-IV math subtests 5. Normal or corrected-to-normal vision and no hearing impairments 6. Inclusion in MRI scan session: Right-handed Exclusion Criteria: 1. History of neurological or psychiatric disorder (i.e., schizophrenia, psychosis, depression, or attention deficit hyperactivity disorder.) 2. History of trauma involving head injury 3. Consistent psychiatric medications 4. Exclusion from MRI scan session: No major contraindication for magnetic resonance imaging (MRI) - braces, metal implants, pacemakers, vascular stents, metallic ear tubes, consistent exposure to metal, claustrophobia)
References
Publications (0)
Data not yet available
No reference posted for this study.