Clinical trial · Interventional
Lung Cancer Screening With Low-dose CT Scan in Women : Implementation Study
NCT05195385CI-TRIAL-00106692CASCADErecruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to determine whether reading of low-dose thoracic CT scans can be done by a single general radiologist who has been trained to lung cancer screening, and will evaluate the performance in comparison with double reading by experts. The study will enroll women between 50 and 74 years old, at risk for lung cancer due to their smoking history.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer Screening | Lung Neoplasm | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Low-dose computed tomography of the chest | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- Procedure
- description
- Baseline low dose Ct acquisition, then at 1 year and 2 years to depict suspicious lung nodules
- interventionNames
- Procedure: Low-dose computed tomography of the chest
Primary outcomes (1)
- measure
- Performance of trained radiologists for lung cancer screening
- timeFrame
- 2 years
- description
- Sensitivity, specificity, predictive values compared to double reading by experts
Secondary outcomes (10)
- measure
- Effectiveness of screening
- timeFrame
- 2 years
- description
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 50 Years
- Maximum age
- 74 Years
Show eligibility criteria text
Inclusion Criteria: * Women aged from 50 to 74 years * who had smoked at least 20 pack years and quit less than 15 years ago * Had given their consent and accepted the need for a 2-year follow-up * Affiliated to the social security system Exclusion Criteria * Presence of clinical symptoms suggesting malignancy (weight loss, hemoptysis) or ongoing infection (cough with fever) * Evolving cancer * History of lung cancer * A 2-year follow-up not possible * Chest CT scan performed within 2 years prior to inclusion
References
Publications (1)
- DERIVEDRevel MP, Abdoul H, Chassagnon G, Canniff E, Durand-Zaleski I, Wislez M. Lung CAncer SCreening in French women using low-dose CT and Artificial intelligence for DEtection: the CASCADE study protocol. BMJ Open. 2022 Dec 8;12(12):e067263. doi: 10.1136/bmjopen-2022-067263. PMID 36600392